Anti-Jo-1 Antibody-positive Interstitial Pneumonia in an Elderly Patient with Congenital Rubella Syndrome

A 71-year-old woman with congenital rubella syndrome (CRS) presented with prolonged cough. No physical findings suggested the presence of any connective tissue diseases. Chest computed tomography showed ground-glass opacities and consolidations in the bilateral lower lobes. She had elevated serum Kr...

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Bibliographic Details
Published in:Internal Medicine 2019/07/15, Vol.58(14), pp.2063-2066
Main Authors: Nozue, Tsuyoshi, Toyoshima, Mikio, Fukada, Atsuki, Suda, Takafumi
Format: Article
Language:English
Subjects:
Alveoli
autoimmunity
Biopsy
Bronchus
Case Report
CD4 antigen
CD8 antigen
Computed tomography
Congenital rubella
congenital rubella syndrome
Connective tissue diseases
Connective tissues
Corticoids
Corticosteroids
Cough
Geriatrics
Hypoxemia
Internal medicine
interstitial pneumonia
Lungs
Lymphocytosis
Pneumonia
Rubella
Vaccines
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Summary:A 71-year-old woman with congenital rubella syndrome (CRS) presented with prolonged cough. No physical findings suggested the presence of any connective tissue diseases. Chest computed tomography showed ground-glass opacities and consolidations in the bilateral lower lobes. She had elevated serum Krebs von den Lungen-6, hypoxemia and positive serum anti-Jo-1 antibody. Bronchoalveolar lavage fluid revealed lymphocytosis with a decreased CD4/CD8 ratio. A transbronchial lung biopsy specimen revealed organizing pneumonia. Based on a diagnosis of interstitial pneumonia with autoimmune features (IPAF), systemic corticosteroids were administered, and a good outcome was obtained. A possible relationship between CRS and IPAF is herein discussed.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.2454-18