Hippocampal volume change following ECT is mediated by rs699947 in the promotor region of VEGF

Several studies have shown that electroconvulsive therapy (ECT) results in increased hippocampal volume. It is likely that a multitude of mechanisms including neurogenesis, gliogenesis, synaptogenesis, angiogenesis, and vasculogenesis contribute to this volume increase. Neurotrophins, like vascular...

Full description

Saved in:
Bibliographic Details
Published in:Translational psychiatry 2019-08, Vol.9 (1), p.191-7, Article 191
Main Authors: Van Den Bossche, Maarten J. A., Emsell, Louise, Dols, Annemiek, Vansteelandt, Kristof, De Winter, François-Laurent, Van den Stock, Jan, Sienaert, Pascal, Stek, Max L., Bouckaert, Filip, Vandenbulcke, Mathieu
Format: Article
Language:English
Subjects:
45/23
59/57
631/208/212/2166
631/208/2489
631/378/340
692/53/2422
692/699/476/1414
Aged
Aged, 80 and over
Behavioral Sciences
Biological Psychology
Brain-derived neurotrophic factor
Depressive Disorder, Major - diagnostic imaging
Depressive Disorder, Major - genetics
Depressive Disorder, Major - therapy
Electroconvulsive Therapy
Female
Hippocampus - diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neurosciences
Organ Size - genetics
Pharmacotherapy
Promoter Regions, Genetic
Psychiatry
Treatment Outcome
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several studies have shown that electroconvulsive therapy (ECT) results in increased hippocampal volume. It is likely that a multitude of mechanisms including neurogenesis, gliogenesis, synaptogenesis, angiogenesis, and vasculogenesis contribute to this volume increase. Neurotrophins, like vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) seem to play a crucial mediating role in several of these mechanisms. We hypothesized that two regulatory SNPs in the VEGF and BDNF gene influence the changes in hippocampal volume following ECT. We combined genotyping and brain MRI assessment in a sample of older adults suffering from major depressive disorder to test this hypothesis. Our results show an effect of rs699947 (in the promotor region of VEGF ) on hippocampal volume changes following ECT. However, we did not find a clear effect of rs6265 (in BDNF ). To the best of our knowledge, this is the first study investigating possible genetic mechanisms involved in hippocampal volume change during ECT treatment.
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-019-0530-6