Circadian rest-activity patterns in bipolar disorder and borderline personality disorder

Bipolar disorder (BD) and borderline personality disorder (BPD) are two psychiatric disorders with overlapping features that can be challenging to separate diagnostically. Growing evidence suggests that circadian rhythm disturbances are associated with psychiatric illness, however circadian patterns...

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Bibliographic Details
Published in:Translational psychiatry 2019-08, Vol.9 (1), p.195-11, Article 195
Main Authors: McGowan, Niall M., Goodwin, Guy M., Bilderbeck, Amy C., Saunders, Kate E. A.
Format: Article
Language:English
Subjects:
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Actigraphy
Adult
Behavioral Sciences
Biological Psychology
Bipolar disorder
Bipolar Disorder - physiopathology
Borderline personality disorder
Borderline Personality Disorder - physiopathology
Circadian rhythm
Circadian Rhythm - physiology
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Motor Activity - physiology
Neurosciences
Personality disorders
Pharmacotherapy
Psychiatry
Rest
Young Adult
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Summary:Bipolar disorder (BD) and borderline personality disorder (BPD) are two psychiatric disorders with overlapping features that can be challenging to separate diagnostically. Growing evidence suggests that circadian rhythm disturbances are associated with psychiatric illness, however circadian patterns of behaviour have not been elucidated in BPD or differentiated from BD. This study compared the circadian structure and timing of rest-activity patterns in BPD with BD and healthy volunteers. Participants with BD ( N  = 31) and BPD ( N  = 21) and healthy controls (HC, N  = 35) wore an actigraph on their non-dominant wrist for 28 day periods as part of the Automated Monitoring of Symptom Severity (AMoSS) study. Non-parametric circadian rhythm analysis of rest-activity patterns and cosinor analysis of distal temperature rhythms were conducted to elucidate circadian function between groups. Covariates controlled for included employment status, BMI and gender. Compared with HC and BD, individuals with BPD showed significantly delayed phase of night-time rest patterns (“L5 onset”) (mean difference = 1:47 h, P  
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-019-0526-2