A proposed mechanism influencing structural patterns in X-linked retinoschisis and stellate nonhereditary idiopathic foveomacular retinoschisis

• Published in: Eye (London) 2019-05, Vol.33 (5), p.724-728
• Main Authors: Fragiotta, Serena, Leong, Belinda C. S., Kaden, Talia R., Bass, Sherry J., Sherman, Jerome, Yannuzzi, Lawrence A., Freund, K. Bailey
• Format: Article
• Language: English
• Subjects: 692/308/409; 692/699/3161/3175; Angiography; Child; Female; Fluorescein Angiography - methods; Humans; Image processing; Laboratory Medicine; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Pharmaceutical Sciences/Technology; Regional Blood Flow - physiology; Retina; Retinal Vessels - diagnostic imaging; Retinal Vessels - pathology; Retinoschisis; Retinoschisis - diagnosis; Retinoschisis - physiopathology; Segmentation; Surgery; Surgical Oncology; Tomography; Tomography, Optical Coherence - methods; Vitelliform Macular Dystrophy - diagnosis; Vitelliform Macular Dystrophy - physiopathology
• ISSN: 0950-222X; 1476-5454
• DOI: 10.1038/s41433-018-0296-8

Objective To explore the structural differences between X-linked retinoschisis (XLR) and stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) using swept-source optical coherence tomography angiography (SS-OCTA). Methods A case series of two patients, a 9-year-old male with XLR and a 58-year-old woman with SNIFR were imaged with swept-source optical coherence tomography angiography (SS-OCTA; PLEX Elite 900, Carl Zeiss Meditec, Inc, Dublin, CA). Automated segmentation was manually adjusted to include the areas of retinoschisis within en face flow and structural slabs. The flow data were binarized using ImageJ 1.51s (Wayne Rasband, National Institutes of Health, USA, http://imagej.nih.gov.ij ) and superimposed onto the structural slab. Results In the eye with XLR, OCTA flow data superimposed on the structural slab demonstrated flow signal within numerous bridging structures connecting the inner and outer plexiform layers containing the intermediate (ICP) and deep (DCP) capillary plexuses. In contrast, the same technique applied to the eye with SNIFR demonstrated an absence of flow signal in the cystic retinal spaces within Henle’s fiber layer. Conclusions The vascular pattern of bridging vessels between the ICP and DCP is closely related to the structural “retinoschisis” pattern of XLR and appears to be structurally different from that seen in SNIFR. Moreover, the connecting vessels appear to be highly represented and regularly distributed, thereby supporting a serial arrangement of the retinal capillary plexuses within the perifoveal macula.