Prediction of neonatal acidosis using the cerebroplacental ratio at different gestational weeks: A case–control study

• Published in: Medicine (Baltimore) 2019-07, Vol.98 (29), p.e16458-e16458
• Main Authors: Guo, Lin-Na, Chai, Yi-Qing, Guo, Shuang, Zhang, Zhi-Kun
• Format: Article
• Language: English
• Subjects: Acidosis - diagnosis; Case-Control Studies; Early Diagnosis; Female; Fetus - metabolism; Fetus - physiopathology; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases - diagnosis; Infant, Newborn, Diseases - metabolism; Infant, Newborn, Diseases - physiopathology; Middle Cerebral Artery - diagnostic imaging; Observational Study; Predictive Value of Tests; Pregnancy; Prenatal Diagnosis - methods; Prognosis; Pulsatile Flow; Ultrasonography, Doppler, Color - methods; Ultrasonography, Prenatal - methods; Umbilical Arteries - diagnostic imaging
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000016458

We evaluated the clinical value of the cerebroplacental ratio (CPR) in predicting neonatal acidosis according to the gestational weeks in late pregnancy.From July 2016 to June 2017, 1018 neonates without acidosis and 218 neonates with acidosis (confirmed postpartum) underwent a prenatal examination and hospital delivery at 28 to 41 weeks in our hospital. The CPR was calculated as the ratio of the prenatal middle cerebral artery-pulsation index (MCA-PI) to the umbilical artery-pulsation index (UA-PI).In neonates without acidosis, the fetal UA-PI decreased with increased gestational age during late pregnancy. Similarly, the MCA-PI decreased with increased gestational age, and decreased significantly during the full pregnancy term. Additionally, the CPR peaked in the middle of the late pregnancy period and then decreased. In contrast, in neonates with acidosis, the prenatal UA-PI increased significantly, MCA-PI declined significantly, and CPR declined significantly in relation to normal values (P