Associations between Health-Related Quality of Life and Self-Reported Emergency Room Department Visits and Inpatient Hospitalizations: Insights from a Secondary Data Analysis of Patients with Light-Chain (AL) Amyloidosis

Introduction Light-chain (AL) amyloidosis is a rare, progressive, and typically fatal disease. Health-related quality of life (HRQoL) has been shown to be a significant prognostic factor associated with clinical outcomes such as survival and response to treatment. A better understanding of how patte...

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Bibliographic Details
Published in:PharmacoEconomics - open 2019-09, Vol.3 (3), p.367-375
Main Authors: McCausland, Kristen L., Rizio, Avery A., White, Michelle K., Bayliss, Martha S., Quock, Tiffany P.
Format: Article
Language:English
Subjects:
Amyloidosis
Data collection
Disease
Emergency medical care
Health care expenditures
Hospitalization
Medicine
Medicine & Public Health
Mental health
Nervous system
Original
Original Research Article
Patients
Pharmacoeconomics and Health Outcomes
Quality of life
Self report
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Summary:Introduction Light-chain (AL) amyloidosis is a rare, progressive, and typically fatal disease. Health-related quality of life (HRQoL) has been shown to be a significant prognostic factor associated with clinical outcomes such as survival and response to treatment. A better understanding of how patterns of HRQoL may be prospectively associated with costly healthcare resource utilization, such as emergency department (ED) visits and inpatient hospitalizations, is warranted. Methods A secondary data analysis of a non-interventional, longitudinal online study of patients with AL amyloidosis ( n  = 224) was conducted. Negative binomial regression models were used to examine whether initial HRQoL scores (as measured by the SF-36v2 ® Health Survey [SF-36v2], where higher scores reflect better HRQoL) and changes in HRQoL were associated with the number of ED visits and inpatient hospitalizations during a 12-month period. Incidence rate ratios were interpreted by 5-point decrements in initial HRQoL scores and minimally important changes in HRQoL change scores. Results There were significant inverse associations between initial SF-36v2 scores and subsequent rates of ED visits and inpatient hospitalizations across all domains and summary components ( p  
ISSN:2509-4262
2509-4254
DOI:10.1007/s41669-019-0122-7