Benefit of Anticoagulation Therapy in Hyperthyroidism‐Related Atrial Fibrillation

ABSTRACT Background Existing data on the risk of ischemic stroke in hyperthyroidism‐related atrial fibrillation (AF) and the impact of long‐term anticoagulation in these patients, particularly those with self‐limiting AF, remain inconclusive. Hypothesis Risk of stroke in hyperthyroidism‐related AF i...

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Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2015-08, Vol.38 (8), p.476-482
Main Authors: Chan, Pak‐Hei, Hai, Jojo, Yeung, Chun‐Yip, Lip, Gregory Y.H., Lam, Karen Siu‐Ling, Tse, Hung‐Fat, Siu, Chung‐Wah
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anticoagulants - therapeutic use
Asian Continental Ancestry Group
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Cardiac arrhythmia
Clinical Investigations
Female
Humans
Hyperthyroidism
Hyperthyroidism - complications
Hyperthyroidism - drug therapy
Incidence
Male
Middle Aged
Preventive medicine
Risk Factors
Stroke
Stroke - epidemiology
Stroke - etiology
Survival Analysis
Warfarin - therapeutic use
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Summary:ABSTRACT Background Existing data on the risk of ischemic stroke in hyperthyroidism‐related atrial fibrillation (AF) and the impact of long‐term anticoagulation in these patients, particularly those with self‐limiting AF, remain inconclusive. Hypothesis Risk of stroke in hyperthyroidism‐related AF is the same as nonhyperthyroid counterparts. Methods This was a single‐center observational study of 9727 Chinese patients with nonvalvular AF from July 1997 to December 2011. Patients with AF diagnosed concomitantly with hyperthyroidism were identified. Primary and secondary endpoints were defined as hospitalization with ischemic stroke and intracranial hemorrhage in the first 2 years. Patient characteristics, duration of AF, and choice of antithrombotic therapy were recorded. Self‐limiting AF was defined as
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.22427