Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial

Severe energy deficits during military operations, produced by significant increases in exercise and limited dietary intake, result in conditions that degrade lean body mass and lower-body muscle function, which may be mediated by concomitant reductions in circulating testosterone. We conducted a th...

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Bibliographic Details
Published in:EBioMedicine 2019-08, Vol.46, p.411-422
Main Authors: Pasiakos, Stefan M., Berryman, Claire E., Karl, J. Philip, Lieberman, Harris R., Orr, Jeb S., Margolis, Lee M., Caldwell, John A., Young, Andrew J., Montano, Monty A., Evans, William J., Vartanian, Oshin, Carmichael, Owen T., Gadde, Kishore M., Johannsen, Neil M., Beyl, Robbie A., Harris, Melissa N., Rood, Jennifer C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anabolism
Biomarkers
Body Composition - drug effects
Body Weight - drug effects
Diet
Dietary Supplements
Energy Metabolism - drug effects
Exercise
Female
Humans
Hypogonadism
Hypothalamic-pituitary-gonadal axis
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - metabolism
Lower-body muscle function
Male
Military operational stress
Muscle mass
Muscles - drug effects
Muscles - metabolism
Proof of Concept Study
Research paper
Semi-starvation
Testosterone - administration & dosage
Young Adult
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Summary:Severe energy deficits during military operations, produced by significant increases in exercise and limited dietary intake, result in conditions that degrade lean body mass and lower-body muscle function, which may be mediated by concomitant reductions in circulating testosterone. We conducted a three-phase, proof-of-concept, single centre, randomised, double-blind, placebo-controlled trial (CinicalTrials.gov, NCT02734238) of non-obese men: 14-d run-in, free-living, eucaloric diet phase; 28-d live-in, 55% exercise- and diet-induced energy deficit phase with (200 mg testosterone enanthate per week, Testosterone, n = 24) or without (Placebo, n = 26) exogenous testosterone; and 14-d recovery, free-living, ad libitum diet phase. Body composition was the primary end point; secondary endpoints included lower-body muscle function and health-related biomarkers. Following energy deficit, lean body mass increased in Testosterone and remained stable in Placebo, such that lean body mass significantly differed between groups [mean difference between groups (95% CI), 2.5 kg (3.3, 1.6); P 
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2019.07.059