Altered polyunsaturated fatty acid levels in relation to proinflammatory cytokines, fatty acid desaturase genotype, and diet in bipolar disorder

Inflammation and altered polyunsaturated fatty acid (PUFA) levels have been implicated in bipolar disorder (BD). A recent genome-wide association study identified a locus in the fatty acid desaturase ( FADS ) gene cluster conferring susceptibility to BD. In this study, we examined PUFA levels in pat...

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Bibliographic Details
Published in:Translational psychiatry 2019-08, Vol.9 (1), p.208-9, Article 208
Main Authors: Koga, Norie, Ogura, Jun, Yoshida, Fuyuko, Hattori, Kotaro, Hori, Hiroaki, Aizawa, Emiko, Ishida, Ikki, Kunugi, Hiroshi
Format: Article
Language:English
Subjects:
13/21
45/77
631/378/340
692/699/476/1333
Adolescent
Adult
Aged
Behavioral Sciences
Biological Psychology
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - genetics
Cytokines
Cytokines - blood
Diet
Fatty Acid Desaturases - genetics
Fatty acids
Fatty Acids, Unsaturated - blood
Female
Genotype
Genotype & phenotype
Humans
Inflammation - blood
Inflammation - genetics
Interleukin-6 - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Neurosciences
Pharmacotherapy
Polymorphism, Single Nucleotide
Polyunsaturated fatty acids
Psychiatry
Surveys and Questionnaires
Tumor Necrosis Factor-alpha - blood
Young Adult
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Summary:Inflammation and altered polyunsaturated fatty acid (PUFA) levels have been implicated in bipolar disorder (BD). A recent genome-wide association study identified a locus in the fatty acid desaturase ( FADS ) gene cluster conferring susceptibility to BD. In this study, we examined PUFA levels in patients with BD in relation to proinflammatory cytokines, FADS genotype, and dietary habits. We enrolled 83 patients with BD and 217 healthy controls who underwent plasma PUFA measurement. A subsample of 65 patients and 90 controls underwent plasma interleukin (IL)-6 and tumor necrosis factor alpha (TNFα) measurement, and three FADS single nucleotide polymorphisms (SNPs) were genotyped. Information on fish consumption was obtained by a self-reported diet history questionnaire. In comparing PUFA levels between patients and controls, significant differences were found for all 7 PUFAs tested. Specifically, n-3 eicosapentaenoic acid (EPA) level was decreased, and n-6 arachidonic acid level was increased in the patients ( p  
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-019-0536-0