Emergence of mobile tigecycline resistance mechanism in Escherichia coli strains from migratory birds in China

Plasmid-mediated antimicrobial resistance has emerged as one of the principal global issues, posing significant threats to public health. Herein, we reported a mobile tigecycline resistance mechanism Tet(X4) on both plasmid and chromosome in Escherichia coli strains from migratory birds in China. Be...

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Published in:Emerging microbes & infections 2019, Vol.8 (1), p.1219-1222
Main Authors: Chen, Chong, Cui, Chao-Yue, Zhang, Yan, He, Qian, Wu, Xiao-Ting, Li, Gong, Liao, Xiao-Ping, Kreiswirth, Barry N., Liu, Ya-Hong, Chen, Liang, Sun, Jian
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antimicrobial agents
Birds - microbiology
China
Chromosomes, Bacterial
Drug Resistance, Bacterial
E coli
eravacycline
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - isolation & purification
Genes, Bacterial
Interspersed Repetitive Sequences
Letter
Microbial Sensitivity Tests
migratory birds
omadacycline
Plasmids
Sequence Homology
tet(X4)
Tetracyclines - pharmacology
Tigecycline - pharmacology
Tigecycline resistance
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creator Chen, Chong
Cui, Chao-Yue
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Chen, Liang
Sun, Jian
description Plasmid-mediated antimicrobial resistance has emerged as one of the principal global issues, posing significant threats to public health. Herein, we reported a mobile tigecycline resistance mechanism Tet(X4) on both plasmid and chromosome in Escherichia coli strains from migratory birds in China. Besides tigecycline, these tet(X4)-positive strains also exhibited elevated MICs to the FDA newly approved tetracycline antibiotics, eravacycline (4 µg/ml) and omadacycline (8 µg/ml). Worrisomely, the tet(X4)-carrying plasmids and chromosome also shared high homology with the plasmids from human. Taken together, Tet(X4) represents another emerging antimicrobial threat and collective efforts from different sectors are needed to control its further spread.
doi_str_mv 10.1080/22221751.2019.1653795
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source Taylor & Francis Open Access; Publicly Available Content Database; PubMed Central
subjects Animals
Anti-Bacterial Agents - pharmacology
Antimicrobial agents
Birds - microbiology
China
Chromosomes, Bacterial
Drug Resistance, Bacterial
E coli
eravacycline
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - isolation & purification
Genes, Bacterial
Interspersed Repetitive Sequences
Letter
Microbial Sensitivity Tests
migratory birds
omadacycline
Plasmids
Sequence Homology
tet(X4)
Tetracyclines - pharmacology
Tigecycline - pharmacology
Tigecycline resistance
title Emergence of mobile tigecycline resistance mechanism in Escherichia coli strains from migratory birds in China
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