Effect of astragalosides on long non-coding RNA expression profiles in rats with adjuvant-induced arthritis

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, which occurs in ~1.0% of the general population. Increasing studies have suggested that long non-coding RNAs (lncRNAs) may serve important roles in various biological processes and may be associated with the pathogenesis of diff...

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Bibliographic Details
Published in:International journal of molecular medicine 2019-10, Vol.44 (4), p.1344-1356
Main Authors: Jiang, Hui, Wu, Fu-Rong, Liu, Jian, Qin, Xiu-Juan, Jiang, Nan-Nan, Li, Wei-Ping
Format: Article
Language:English
Subjects:
Animals
Ankle
Arthritis
Asian medicine
Chinese medicine
Computational biology
Cytokines
Drug dosages
Edema
Etiology (Medicine)
Experiments
Genes
Health aspects
Hemoglobin
Instrument industry (Equipment)
Kinases
Messenger RNA
Metabolism
Oxidation
Polymerase chain reaction
Proteins
Rheumatoid factor
RNA
Statistical analysis
Traditional Chinese medicine
Tumor necrosis factor-TNF
Variance analysis
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Summary:Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, which occurs in ~1.0% of the general population. Increasing studies have suggested that long non-coding RNAs (lncRNAs) may serve important roles in various biological processes and may be associated with the pathogenesis of different types of disease, including RA. Astragalosides (AST) has been used as a traditional Chinese medicine for the treatment of RA. However, the mechanism underlying its therapeutic effect has remained unclear to date. Thus, there is an urgent need to elucidate the possible mechanism of AST in the treatment of RA from the perspective of lncRNAs. In the present study, the lncRNAs and mRNAs of a vehicle group, animal model group and AST treatment (control) group were determined by Arraystar Rat IncRNA/mRNA microarray. The differentially expressed genes with a fold change >1.5 and P
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2019.4281