Killing Mycobacterium tuberculosis In Vitro : What Model Systems Can Teach Us

Tuberculosis is one of the most successful human diseases in our history due in large part to the multitude of virulence factors exhibited by the causative agent, . Understanding the pathogenic nuances of this organism in the context of its human host is an ongoing topic of study facilitated by isol...

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Bibliographic Details
Published in:Microbiology spectrum 2017-06, Vol.5 (3)
Main Authors: Keiser, Tracy L, Purdy, Georgiana E
Format: Article
Language:English
Subjects:
Animals
Antitubercular Agents - pharmacology
Cell Death
Cell Line
Humans
Immunity, Innate
In Vitro Techniques
In Vitro Techniques - methods
Macrophages - microbiology
Mice
Models, Biological
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - metabolism
Mycobacterium tuberculosis - pathogenicity
Pathogenesis
Phagosomes
Tuberculosis
Tuberculosis - immunology
Tuberculosis - microbiology
Virulence Factors - metabolism
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Summary:Tuberculosis is one of the most successful human diseases in our history due in large part to the multitude of virulence factors exhibited by the causative agent, . Understanding the pathogenic nuances of this organism in the context of its human host is an ongoing topic of study facilitated by isolating cells from model organisms such as mice and non-human primates. However, is an obligate intracellular human pathogen, and disease progression and outcome in these model systems can differ from that of human disease. Current models of infection include primary macrophages and macrophage-like immortalized cell lines as well as the induced pluripotent stem cell-derived cell types. This article will discuss these model systems in general, what we have learned so far about utilizing them to answer questions about pathogenesis, the potential role of other cell types in innate control of infection, and the development of new coculture systems with multiple cell types. As we continue to expand current systems and institute new ones, the knowledge gained will improve our understanding of not only tuberculosis but all infectious diseases.
ISSN:2165-0497
2165-0497
DOI:10.1128/microbiolspec.TBTB2-0028-2016