Carcinogenic risk of human papillomavirus (HPV) genotypes and potential effects of HPV vaccines in Korea

• Published in: Scientific reports 2019-08, Vol.9 (1), p.12556-9, Article 12556
• Main Authors: Park, Eunhyang, Kim, Ji-Ye, Choi, Sangjoon, Kim, Dae Shick, Oh, Young Lyun
• Format: Article
• Language: English
• Subjects: 13/56; 631/67/1517/1371; 631/67/2322; 631/67/2324; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Carcinogenesis; Carcinogens; Cervical cancer; Cervix; Female; Genotype; Genotypes; Human papillomavirus; Humanities and Social Sciences; Humans; Middle Aged; multidisciplinary; Papillomaviridae - genetics; Papillomaviridae - immunology; Papillomaviridae - physiology; Papillomavirus Vaccines - pharmacology; Precancerous Conditions - pathology; Precancerous Conditions - prevention & control; Precancerous Conditions - virology; Republic of Korea; Risk; Science; Science (multidisciplinary); Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - prevention & control; Uterine Cervical Neoplasms - virology; Vaccines; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-49060-w

This study investigated the distribution of HPV types in Korean women and evaluated the carcinogenic risk of individual HPV types and the potential effects of HPV vaccines. A total of 4,081 HPV-positive samples between 2014 and 2017 were included. The most prevalent genotypes were HPV 16, 58, 68, and 56. Among them, HPV 16 was significantly higher in high-grade squamous intraepithelial neoplasia or worse (HSIL+ ) group. In cytologically evaluating the risk for HSIL+ by individual HPV types, HPV 16 was associated with the highest risk of HSIL+ (OR = 10.82; 95% CI: 7.93–14.77), followed by HPV 33, 31, 52, 18, 58, 51, and 35, in descending order (OR = 3.50 [type 33] to 2.62 [type 35]). Among those types, HPV 16, 18, 31, 33, and 58 were also significantly associated with HSIL+ on histologic evaluation. The analysis of the HPV subgroups covered by the different vaccines revealed that the HPV types covered by the 9-valent vaccine had a high association with HSIL+ (OR = 4.09; 95% CI: 3.02–5.54). Our findings highlight the different carcinogenic risks posed by the high risk HPV genotypes and the positive potential effects of the 9-valent HPV vaccine in reducing HPV-associated cervical cancer in Korea.