Development of a novel fungicide, tolprocarb

Tolprocarb developed by Mitsui Chemicals Agro, Inc. (Tokyo, Japan) was discovered as a new oomycete fungicide. However, its antifungal spectrum and action mechanisms against fungi are completely different from those of the original compound, iprovalicarb. Tolprocarb has a potent and highly controlle...

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Bibliographic Details
Published in:Journal of Pesticide Science 2019/08/20, Vol.44(3), pp.208-213
Main Authors: Hagiwara, Hiroyuki, Ezaki, Ryutaro, Hamada, Takahiro, Tsuda, Mikio, Ebihara, Koichi
Format: Article
Language:English
Subjects:
Agricultural production
Bacterial diseases
Biosynthesis
Cross-resistance
Cytochrome
Cytochrome bc1
Cytochromes
Dehydration
Fungi
Fungicides
Health risks
Inhibitors
Magnaporthe grisea
MBI-P
Melanin
Melanin biosynthesis inhibitor
Mode of action
Organic chemistry
Oryza sativa
Pesticides
Polyketide synthase
Quinones
Rice
Rice blast
Rice fields
Society Awards 2019
Systemic acquired resistance
Xanthomonas oryzae pv. oryzae
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Summary:Tolprocarb developed by Mitsui Chemicals Agro, Inc. (Tokyo, Japan) was discovered as a new oomycete fungicide. However, its antifungal spectrum and action mechanisms against fungi are completely different from those of the original compound, iprovalicarb. Tolprocarb has a potent and highly controlled effect on a rice blast fungus Magnaporthe grisea, and its mode of action was revealed to be the inhibition of polyketide synthase in the melanin biosynthesis pathway. In addition, tolprocarb induced systemic acquired resistance in Arabidopsis thaliana and rice (Oryza sativa L.). Owing to these double modes of action, tolprocarb can effectively control not only rice blast but also bacterial diseases, and has a low risk of developing fungicide-resistant isolates. Tolprocarb also provides long-term residual activity. A meta-analysis was performed in order to demonstrate tolprocarb’s superior control against panicle blast in paddy fields. In addition, tolprocarb did not show cross-resistance against the fungi that are resistant to dehydratase inhibitor in melanin biosynthesis (Melanin Biosynthesis Inhibitor-Dehydratase; MBI-D) or respiratory complex III: cytochrome bc1 at Quinone outside site inhibitor (Quinone outside Inhibitor; QoI). Owing to its stable effects, tolprocarb appears to be a suitable choice for practical use against fungi in the rice production field.
ISSN:1348-589X
1349-0923
DOI:10.1584/jpestics.J19-01