Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System

The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulat...

Full description

Saved in:
Bibliographic Details
Published in:ACS chemical neuroscience 2018-09, Vol.9 (9), p.2146-2161
Main Authors: Augustin, Shana M, Lovinger, David M
Format: Article
Language:English
Subjects:
Amygdala - metabolism
Amygdala - physiology
Animals
Arachidonic Acids - metabolism
Arachidonic Acids - physiology
Behavior, Addictive - metabolism
Behavior, Addictive - physiopathology
Brain - metabolism
Brain - physiology
Cerebellum - metabolism
Cerebellum - physiology
Cerebral Cortex - metabolism
Cerebral Cortex - physiology
Conditioning, Psychological - physiology
Corpus Striatum - metabolism
Corpus Striatum - physiology
Endocannabinoids - metabolism
Endocannabinoids - physiology
Extinction, Psychological - physiology
Fear
Glycerides - metabolism
Glycerides - physiology
Goals
Hippocampus - metabolism
Hippocampus - physiology
Humans
Neural Pathways
Neuronal Plasticity
Polyunsaturated Alkamides - metabolism
Receptors, Cannabinoid - metabolism
Receptors, Cannabinoid - physiology
Reward
Spatial Learning - physiology
Ventral Striatum - metabolism
Ventral Striatum - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulate behaviors. In particular, we will discuss the behavioral consequences of eCB mediated long-term synaptic plasticity in different brain regions. This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies.
ISSN:1948-7193
1948-7193
DOI:10.1021/acschemneuro.7b00508