BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work

and genes are involved in DNA double-strand break repair and related to breast cancer. Shift work is associated with biological clock alterations and with a higher risk of breast cancer. The aim of this study was to investigate the variability of expression of genes through the day in healthy subjec...

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Bibliographic Details
Published in:Cancers 2019-08, Vol.11 (8), p.1146
Main Authors: Bracci, Massimo, Ciarapica, Veronica, Zabaleta, Maria Eléxpuru, Tartaglione, Maria Fiorella, Pirozzi, Silvia, Giuliani, Letizia, Piva, Francesco, Valentino, Matteo, Ledda, Caterina, Rapisarda, Venerando, Stevens, Richard G, Santarelli, Lory
Format: Article
Language:English
Subjects:
Biological clocks
BRCA1 protein
BRCA2 protein
Breast cancer
Cell cycle
Circadian rhythm
Daytime
Deoxyribonucleic acid
Diurnal variations
DNA
DNA damage
DNA repair
Double-strand break repair
Gene expression
Hormones
Independent sample
Light
Lymphocytes
Melatonin
Mutation
Shift work
Statistical analysis
Workers
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Summary:and genes are involved in DNA double-strand break repair and related to breast cancer. Shift work is associated with biological clock alterations and with a higher risk of breast cancer. The aim of this study was to investigate the variability of expression of genes through the day in healthy subjects and to measure expression levels in shift workers. The study was approached in two ways. First, we examined diurnal variation of and genes in lymphocytes of 15 volunteers over a 24-hour period. Second, we measured the expression of these genes in lymphocytes from a group of shift and daytime workers. The change in 24-hour expression levels of and genes was statistically significant, decreasing from the peak at midday to the lowest level at midnight. Lower levels for both genes were found in shift workers compared to daytime workers. Diurnal variability of and expression suggests a relation of DNA double-strand break repair system with biological clock. Lower levels of and found in shift workers may be one of the potential factors related to the higher risk of breast cancer.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11081146