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Endothelium-Dependent Vasorelaxant Effect of Prunus Persica Branch on Isolated Rat Thoracic Aorta
Peach ( (L.) Batsch) is a popular fruit consumed by people worldwide, owing to its pleasant flavor and high mineral nutrient content. A few plants from the genus , such as , , and have shown vasorelaxant and vasodilatory effects, to date, no study has investigated the vasorelaxation effects of the b...
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Published in: | Nutrients 2019-08, Vol.11 (8), p.1816 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Peach (
(L.) Batsch) is a popular fruit consumed by people worldwide, owing to its pleasant flavor and high mineral nutrient content. A few plants from the genus
, such as
,
, and
have shown vasorelaxant and vasodilatory effects, to date, no study has investigated the vasorelaxation effects of the
branch extract (PPE). The vasorelaxant effect of PPE was endothelium-dependent, and it was related to the NO-sGC-cGMP, vascular prostacyclin, and muscarinic receptor transduction pathway. K
channels, such as the BK
, K
, and K
channels, were partially associated with PPE-induced vasorelaxation. PPE was effective in relaxing serotonin (5-HT)- or angiotensin II-induced contraction; furthermore, PPE attenuated Ca
-induced vasoconstriction by IP
receptors in the SR membrane, but its vasorelaxant effect was not associated with the influx of extracellular Ca
via receptor-operative Ca
channels or voltage-dependent Ca
channels. Recognizing the rising use of functional foods for hypertension treatment, our findings imply that PPE may be a natural antihypertensive agent. |
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ISSN: | 2072-6643 2072-6643 |
DOI: | 10.3390/nu11081816 |