(PVA/Chitosan/Fucoidan)-Ampicillin: A Bioartificial Polymeric Material with Combined Properties in Cell Regeneration and Potential Antibacterial Features

Chitosan, fucoidan, and polyvinyl alcohol are categorized as polymers with biomedical applications. Ampicillin, on the other hand, is considered as an important antibiotic that has shown effectivity in both gram-positive and gram-negative micro-organisms. The aforementioned polymers possess unique p...

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Bibliographic Details
Published in:Polymers 2019-08, Vol.11 (8), p.1325
Main Authors: Bernal-Ballen, Andres, Lopez-Garcia, Jorge-Andres, Ozaltin, Kadir
Format: Article
Language:English
Subjects:
Ampicillin
Antibiotics
Aqueous solutions
Biocompatibility
Biological properties
Biomedical materials
Biopolymers
Chitosan
Fourier transforms
Hydrochloric acid
Mechanical properties
Natural polymers
Polymers
Polyvinyl alcohol
Regeneration
Solubility
Statistical methods
Swelling
Tissue engineering
Variance analysis
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Summary:Chitosan, fucoidan, and polyvinyl alcohol are categorized as polymers with biomedical applications. Ampicillin, on the other hand, is considered as an important antibiotic that has shown effectivity in both gram-positive and gram-negative micro-organisms. The aforementioned polymers possess unique properties that are considered desirable for cell regeneration although they exhibit drawbacks that can affect their final application. Therefore, films of these biomaterials were prepared and they were characterized using FTIR, SEM, XRD, degree of swelling and solubility, and MTT assay. The statistical significance of the experiments was determined using a two-way analysis of variance (ANOVA) with < 0.05. The characterization techniques demonstrated that the obtained material exhibits properties suitable for cell regeneration, and that a higher concentration of natural polymers promotes cells proliferation to a greater extent. The presence of PVA, on the other hand, is responsible for matrix stability and dictates the degree of swelling and solubility. The SEM images demonstrated that neither aggregations nor clusters were formed, which is favorable for the biological properties without detrimental to the morphological and physical features. Cell viability was comparatively similar in samples with and without antibiotic, and the physical and biological properties were not negatively affected. Indeed, the inherent bactericidal effect of chitosan was reinforced by the presence of ampicillin. The new material is an outstanding candidate for cell regeneration as a consequence of the synergic effect that each component provides to the blend.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym11081325