Tissue‐engineered 3D microvessel and capillary network models for the study of vascular phenomena

Advances in tissue engineering, cell biology, microfabrication, and microfluidics have led to the development of a wide range of vascular models. Here, we review platforms based on templated microvessel fabrication to generate increasingly complex vascular models of (i) the tumor microenvironment, (...

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Bibliographic Details
Published in:Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2017-07, Vol.24 (5), p.n/a
Main Authors: Bogorad, Max I., DeStefano, Jackson, Wong, Andrew D., Searson, Peter C.
Format: Article
Language:English
Subjects:
capillary networks
Endothelium, Vascular
Humans
metastasis
microfabrication
microfluidics
microvascular models
Microvessels
Models, Cardiovascular
self‐organization
templating
Tissue engineering
Tissue Engineering - methods
vessel occlusion
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Summary:Advances in tissue engineering, cell biology, microfabrication, and microfluidics have led to the development of a wide range of vascular models. Here, we review platforms based on templated microvessel fabrication to generate increasingly complex vascular models of (i) the tumor microenvironment, (ii) occluded microvessels, and (iii) perfused capillary networks. We outline fabrication guidelines and demonstrate a number of experimental methods for probing vascular function such as permeability measurements, tumor cell intravasation, flow characterization, and endothelial cell morphology and proliferation.
ISSN:1073-9688
1549-8719
DOI:10.1111/micc.12360