Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion

ATP binding cassette transporter A1 (ABCA1) is a membrane transporter that facilitates nascent HDL formation. Tangier disease subjects with complete ABCA1 deficiency have

Saved in:
Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular and cell biology of lipids 2017-10, Vol.1862 (10), p.1035-1043
Main Authors: Liu, Mingxia, Chung, Soonkyu, Shelness, Gregory S., Parks, John S.
Format: Article
Language:English
Subjects:
ABC transporters
albumins
Animals
apolipoprotein B
Apolipoproteins B - genetics
Apolipoproteins B - metabolism
ATP Binding Cassette Transporter 1 - genetics
ATP Binding Cassette Transporter 1 - metabolism
Cell Line, Tumor
Endoplasmic reticulum
fibroblasts
fluorescence
Gene Silencing
Golgi apparatus
HDL deficiency
hepatocytes
Hepatocytes - metabolism
hepatoma
high density lipoprotein
knockout mutants
Lipoproteins, VLDL - genetics
Lipoproteins, VLDL - metabolism
Liver - metabolism
Liver - pathology
macrophages
Mice
Mice, Knockout
phenotype
protein transport
Protein Transport - physiology
Rats
secretion
triacylglycerols
Triglycerides - genetics
Triglycerides - metabolism
very low density lipoprotein
Vesicular trafficking
VLDL1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ATP binding cassette transporter A1 (ABCA1) is a membrane transporter that facilitates nascent HDL formation. Tangier disease subjects with complete ABCA1 deficiency have
ISSN:1388-1981
1879-2618
DOI:10.1016/j.bbalip.2017.07.001