Mts1 Up-regulation is Associated With Aggressive Pathological Features in Thyroid Cancer

Background/Aim: Thyroid cancer is the most common type of endocrine cancer and its incidence and mortality are increasing. However, few studies on the molecular factors related to its poor prognosis have been performed. The aim of our study was to identify a poor prognostic factor for thyroid cancer...

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Bibliographic Details
Published in:Cancer genomics & proteomics 2019-09, Vol.16 (5), p.369-376
Main Authors: CHEON, MIN GYEONG, SON, YE WON, LEE, JOON-HYOP, JANG, HO HEE, CHUNG, YOO SEUNG
Format: Article
Language:English
Subjects:
Cancer
Health risk assessment
Lymph nodes
Metastases
Metastasis
Mortality
Papillary thyroid cancer
Prognosis
S100 protein
Thyroid
Thyroid cancer
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Summary:Background/Aim: Thyroid cancer is the most common type of endocrine cancer and its incidence and mortality are increasing. However, few studies on the molecular factors related to its poor prognosis have been performed. The aim of our study was to identify a poor prognostic factor for thyroid cancer to reduce its overtreatment, recurrence, and mortality. Materials and Methods: The present study is a retrospective study of 55 patients who were diagnosed with papillary thyroid cancer and operated in Korea from September 2013 to November 2015. Results: Mts1 is a member of the S100 protein family and is involved in tumor progression and metastasis. Mts1 was highly expressed in patients with thyroid cancer and high Mts1 levels were related to poor prognoses such as lymph node metastasis. Conclusion: Mts1 is associated with aggressive pathological features in thyroid cancer, and may be a poor prognostic factor for thyroid cancer.
ISSN:1109-6535
1790-6245
DOI:10.21873/cgp.20142