Shifting Landscape of Airway Infection in Early Cystic Fibrosis

[...]many microbiology laboratories do not routinely test for fungi in OP swabs because of low diagnostic yield. Because most CF centers rely on OP samples for pathogen surveillance in younger children with CF, fungi such as Aspergillus will not be detected. Restoring cystic fibrosis transmembrane c...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2019-09, Vol.200 (5), p.528-529
Main Authors: Hoppe, Jordana E, Sagel, Scott D
Format: Article
Language:English
Subjects:
Antibiotics
Child
Child, Preschool
Clinical outcomes
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Cysts
Epidemiology
Fungi
Health surveillance
Humans
Lung diseases
Medical screening
Newborn babies
Prevalence
Respiratory System
Staphylococcus infections
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Summary:[...]many microbiology laboratories do not routinely test for fungi in OP swabs because of low diagnostic yield. Because most CF centers rely on OP samples for pathogen surveillance in younger children with CF, fungi such as Aspergillus will not be detected. Restoring cystic fibrosis transmembrane conductance regulator function reduces airway bacteria and inflammation in people with cystic fibrosis and chronic lung infections. Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201903-0529ED