Nociception and the neonatal brain

AbstractMeasuring brain activity in infants provides an objective surrogate approach with which to infer pain perception following noxious events. Here we discuss different approaches which can be used to measure noxious-evoked brain activity, and discuss how these measures can be used to assess the...

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Bibliographic Details
Published in:Seminars in fetal & neonatal medicine 2019-08, Vol.24 (4), p.101016-101016, Article 101016
Main Authors: Gursul, Deniz, Hartley, Caroline, Slater, Rebeccah
Format: Article
Language:English
Subjects:
Analgesia
Analgesics, Opioid - therapeutic use
Anesthetics, Local - therapeutic use
Brain - physiology
Clinical trials
Development
Electroencephalography
Electromyography
Evoked potentials
Evoked Potentials - physiology
Facial expressions
Gestational Age
Humans
Infant Behavior - physiology
Infant, Newborn
Magnetic Resonance Imaging
Morphine - therapeutic use
Near-infrared spectroscopy
Neonatal and Perinatal Medicine
Neonate
Neuroimaging
Nociception
Nociception - physiology
Pain measurement
Pain Measurement - methods
Sex Factors
Spectroscopy, Near-Infrared
Stress, Psychological - physiopathology
Sucrose - administration & dosage
Touch
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Summary:AbstractMeasuring brain activity in infants provides an objective surrogate approach with which to infer pain perception following noxious events. Here we discuss different approaches which can be used to measure noxious-evoked brain activity, and discuss how these measures can be used to assess the analgesic efficacy of pharmacological and non-pharmacological interventions. We review factors that can modulate noxious-evoked brain activity, which may impact infant pain experience, including gestational age, sex, prior pain, stress, and illness.
ISSN:1744-165X
1878-0946
DOI:10.1016/j.siny.2019.05.008