Cell Adhesion Molecules in Synapse Formation

Neuronal transmission relies on signals transmitted through a vast array of excitatory and inhibitory neuronal synaptic connections. How do axons communicate with dendrites to build synapses, and what molecules regulate this interaction? There is a wealth of evidence suggesting that cell adhesion mo...

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Bibliographic Details
Published in:The Journal of neuroscience 2004-10, Vol.24 (42), p.9244-9249
Main Authors: Washbourne, Philip, Dityatev, Alexander, Scheiffele, Peter, Biederer, Thomas, Weiner, Joshua A, Christopherson, Karen S, El-Husseini, Alaa
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Cell Adhesion Molecules - physiology
Dendrites - physiology
Humans
Symposia and Mini-Symposia
Synapses - physiology
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Summary:Neuronal transmission relies on signals transmitted through a vast array of excitatory and inhibitory neuronal synaptic connections. How do axons communicate with dendrites to build synapses, and what molecules regulate this interaction? There is a wealth of evidence suggesting that cell adhesion molecules (CAMs) provide much of the information required for synapse formation. This review highlights the molecular mechanisms used by CAMs to regulate presynaptic and postsynaptic differentiation.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.3339-04.2004