A "Synaptoplasmic Cistern" Mediates Rapid Inhibition of Cochlear Hair Cells

Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CIC...

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Bibliographic Details
Published in:The Journal of neuroscience 2004-12, Vol.24 (49), p.11160-11164
Main Authors: Lioudyno, Maria, Hiel, Hakim, Kong, Jee-Hyun, Katz, Eleonora, Waldman, Erik, Parameshwaran-Iyer, Suchitra, Glowatzki, Elisabeth, Fuchs, Paul A
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Brief Communications
Calcium - metabolism
Calcium - physiology
Electrophysiology
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum - physiology
Evoked Potentials - drug effects
Evoked Potentials - physiology
Hair Cells, Auditory - drug effects
Hair Cells, Auditory - metabolism
Hair Cells, Auditory - physiology
Hair Cells, Auditory - ultrastructure
In Vitro Techniques
Neural Inhibition - physiology
Patch-Clamp Techniques
Potassium - physiology
Rats
Rats, Sprague-Dawley
Receptors, Nicotinic - physiology
Ryanodine Receptor Calcium Release Channel - physiology
Synapses - metabolism
Synapses - physiology
Synapses - ultrastructure
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Summary:Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea. Consistent with this finding, ryanodine and other store-active compounds alter the amplitude of transient currents produced by synaptic release of ACh, as well as the response of the hair cell to exogenous ACh. Like the sarcoplasmic reticulum of muscle, the "synaptoplasmic" cistern of the hair cell efficiently couples synaptic input to CICR.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.3674-04.2004