Clinical Model for Predicting Warfarin Sensitivity

Warfarin is a widely used anticoagulant with a narrow therapeutic index and large interpatient variability in the therapeutic dose. Complications from inappropriate warfarin dosing are one of the most common reasons for emergency room visits. Approximately one third of warfarin dose variability resu...

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Bibliographic Details
Published in:Scientific reports 2019-09, Vol.9 (1), p.12856-9, Article 12856
Main Authors: Ma, Zhiyuan, Cheng, Gang, Wang, Ping, Khalighi, Bahar, Khalighi, Koroush
Format: Article
Language:English
Subjects:
692/308/2056
692/4019/592
Aged
Aged, 80 and over
Algorithms
Anticoagulants
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Cohort Studies
Cytochrome P-450 CYP2C9 - genetics
Dosage
Drug Resistance - genetics
Emergency medical care
Female
Genetic diversity
Genetic variance
Genotype
Humanities and Social Sciences
Humans
Logistic Models
Male
Metabolism, Inborn Errors - chemically induced
Metabolism, Inborn Errors - diagnosis
Metabolism, Inborn Errors - genetics
Middle Aged
multidisciplinary
Pharmacogenomic Variants - genetics
Polymorphism, Single Nucleotide
Prognosis
Science
Science (multidisciplinary)
Vitamin K Epoxide Reductases - genetics
Warfarin
Warfarin - adverse effects
Warfarin - therapeutic use
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Summary:Warfarin is a widely used anticoagulant with a narrow therapeutic index and large interpatient variability in the therapeutic dose. Complications from inappropriate warfarin dosing are one of the most common reasons for emergency room visits. Approximately one third of warfarin dose variability results from common genetic variants. Therefore, it is very necessary to recognize warfarin sensitivity in individuals caused by genetic variants. Based on combined polymorphisms in CYP2C9 and VKORC1 , we established a clinical classification for warfarin sensitivity. In the International Warfarin Pharmacogenetic Consortium (IWPC) with 5542 patients, we found that 95.1% of the Black in the IWPC cohort were normal warfarin responders, while 74.8% of the Asian were warfarin sensitive (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-49329-0