Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma

Glioblastoma is a hostile brain tumor associated with high infiltration leading to poor prognosis. Anti-cancer chemotherapeutic agents have limited access into the brain due to the presence of the blood brain barrier (BBB). In this study, we designed a dual functionalized liposomal delivery system,...

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Bibliographic Details
Published in:Journal of controlled release 2019-08, Vol.307, p.247-260
Main Authors: Lakkadwala, Sushant, dos Santos Rodrigues, Bruna, Sun, Chengwen, Singh, Jagdish
Format: Article
Language:English
Subjects:
Blood brain barrier
Combination drug therapy
Dual functionalized liposomes
Glioblastoma
in vitro brain tumor model
Targeted drug delivery
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Summary:Glioblastoma is a hostile brain tumor associated with high infiltration leading to poor prognosis. Anti-cancer chemotherapeutic agents have limited access into the brain due to the presence of the blood brain barrier (BBB). In this study, we designed a dual functionalized liposomal delivery system, surface modified with transferrin (Tf) for receptor mediated transcytosis and a cell penetrating peptide-penetratin (Pen) for enhanced cell penetration. We loaded doxorubicin and erlotinib into liposomes to enhance their translocation across the BBB to glioblastoma tumor. In vitro cytotoxicity and hemocompatibility studies demonstrated excellent biocompatibility for in vivo administration. Co-delivery of doxorubicin and erlotinib loaded Tf-Pen liposomes revealed significantly (p 
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2019.06.033