Cell migration and axon guidance at the border between central and peripheral nervous system

The central and peripheral nervous system (CNS and PNS, respectively) are composed of distinct neuronal and glial cell types with specialized functional properties. However, a small number of select cells traverse the CNS-PNS boundary and connect these two major subdivisions of the nervous system. T...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2019-08, Vol.365 (6456), p.881-881
Main Authors: Suter, Tracey A. C. S., Jaworski, Alexander
Format: Article
Language:English
Subjects:
Accident Prevention
Anatomy
Animals
Astrocytes - physiology
Axon Guidance
Axons
Basement Membrane
Boundaries
Brain
Cell adhesion & migration
Cell body
Cell migration
Cell Movement
Central nervous system
Central Nervous System - cytology
Central Nervous System - embryology
Circuits
Compartments
Developmental plasticity
Embryogenesis
Embryonic growth stage
Ganglia
Glial cells
Glial stem cells
Guidance
Hindbrain
Housing
Invertebrates
Migration
Molecular modelling
Motor neurons
Nerves
Nervous system
Neural crest
Neural networks
Neural stem cells
Neurodegenerative diseases
Neuroglia - physiology
Neurological diseases
Neuronal-glial interactions
Neurons
Neurons - physiology
Peripheral nervous system
Peripheral Nervous System - cytology
Peripheral Nervous System - embryology
Plastic properties
Plasticity
Regeneration
Residential areas
REVIEW SUMMARY
Sensory neurons
Signal transduction
Signaling
Spinal cord
Subdivisions
Subsystems
Vertebrates
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Description
Summary:The central and peripheral nervous system (CNS and PNS, respectively) are composed of distinct neuronal and glial cell types with specialized functional properties. However, a small number of select cells traverse the CNS-PNS boundary and connect these two major subdivisions of the nervous system. This pattern of segregation and selective connectivity is established during embryonic development, when neurons and glia migrate to their destinations and axons project to their targets. Here, we provide an overview of the cellular and molecular mechanisms that control cell migration and axon guidance at the vertebrate CNS-PNS border. We highlight recent advances on how cell bodies and axons are instructed to either cross or respect this boundary, and present open questions concerning the development and plasticity of the CNS-PNS interface.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aaw8231