A Novel Test for Absolute Fit of Evolutionary Models Provides a Means to Correctly Identify the Substitution Model and the Model Tree

Abstract A novel test is described that visualizes the absolute model-data fit of the substitution and tree components of an evolutionary model. The test utilizes statistics based on counts of character state matches and mismatches in alignments of observed and simulated sequences. This comparison i...

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Bibliographic Details
Published in:Genome biology and evolution 2019-08, Vol.11 (8), p.2403-2419
Main Author: Goremykin, Vadim
Format: Article
Language:English
Subjects:
Biological Evolution
Computational Biology - methods
Computer Simulation
DNA - genetics
Genetic Variation
Humans
Models, Genetic
Phylogeny
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Summary:Abstract A novel test is described that visualizes the absolute model-data fit of the substitution and tree components of an evolutionary model. The test utilizes statistics based on counts of character state matches and mismatches in alignments of observed and simulated sequences. This comparison is used to assess model-data fit. In simulations conducted to evaluate the performance of the test, the test estimator was able to identify both the correct tree topology and substitution model under conditions where the Goldman–Cox test—which tests the fit of a substitution model to sequence data and is also based on comparing simulated replicates with observed data—showed high error rates. The novel test was found to identify the correct tree topology within a wide range of DNA substitution model misspecifications, indicating the high discriminatory power of the test. Use of this test provides a practical approach for assessing absolute model-data fit when testing phylogenetic hypotheses.
ISSN:1759-6653
1759-6653
DOI:10.1093/gbe/evz167