Early-Life Growth and Benign Breast Disease

Abstract Using prospective data from the Early Determinants of Mammographic Density study (United States, 1959–2008, n = 1121), we examined the associations between maternal body size, birth size, and infant and early childhood growth during 3 time periods (0–4 months, 4–12 months, and 1–4 years) an...

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Bibliographic Details
Published in:American journal of epidemiology 2019-09, Vol.188 (9), p.1646-1654
Main Authors: Goldberg, Mandy, Cohn, Barbara A, Houghton, Lauren C, Flom, Julie D, Wei, Ying, Cirillo, Piera, Michels, Karin B, Terry, Mary Beth
Format: Article
Language:English
Subjects:
Adult
Birth Weight
Body mass
Body Mass Index
Body Size
Body weight gain
Breast cancer
Breast Diseases
Child, Preschool
Children
Confidence intervals
Growth
Humans
Infant
Mammography
Mothers
Original Contributions
Prospective Studies
Statistical analysis
Weight Gain
Young Adult
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Summary:Abstract Using prospective data from the Early Determinants of Mammographic Density study (United States, 1959–2008, n = 1121), we examined the associations between maternal body size, birth size, and infant and early childhood growth during 3 time periods (0–4 months, 4–12 months, and 1–4 years) and benign breast disease (BBD) using multivariable logistic regression with generalized estimating equations. A total of 197 women (17.6%) reported receiving a diagnosis of BBD by a physician. Higher body mass index at age 7 years was inversely associated with BBD risk. Rapid weight gain from age 1 year to 4 years, defined as an increase of least 2 major percentiles (e.g., 5th, 10th, 25th, 50th, 75th, and 95th) relative to stable growth, defined as remaining within 2 percentiles, was also inversely associated with BBD (odds ratio (OR) = 0.51, 95% confidence interval (CI): 0.23, 1.15). In contrast, rapid weight gain in infancy was positively associated with BBD relative to stable growth (from 0 to 4 months, OR = 1.65, 95% CI: 1.04, 2.62; from 4 to 12 months, 1.85, 95% CI: 0.89, 3.85), independent of birth weight, which was not associated with BBD. Our results suggest that patterns of early-life weight gain are important to BBD risk. Thus, susceptibility to BBD, like susceptibility to breast cancer, might start in early life.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwz126