Increased expression of miR-153 predicts poor prognosis for patients with prostate cancer

Deregulation of miR-153 has recently been observed in several common human cancer, while miR-153 serves an oncogene or tumor suppressive role in different cancer types. Previously, miR-153 has been identified to be overexpressed in prostate cancer. miR-153 played an important role in promoting proli...

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-09, Vol.98 (36), p.e16705-e16705
Main Authors: Bi, Cheng-wei, Zhang, Guo-ying, Bai, Yu, Zhao, Bin, Yang, Hong
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor
Disease-Free Survival
Humans
Kaplan-Meier Estimate
Male
MicroRNAs - biosynthesis
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Observational Study
Prognosis
Prostatic Neoplasms - mortality
Prostatic Neoplasms - pathology
Reverse Transcriptase Polymerase Chain Reaction
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Summary:Deregulation of miR-153 has recently been observed in several common human cancer, while miR-153 serves an oncogene or tumor suppressive role in different cancer types. Previously, miR-153 has been identified to be overexpressed in prostate cancer. miR-153 played an important role in promoting proliferation of human prostate cancer cells and presented a novel mechanism of microRNA-mediated direct suppression of phosphatase and tensin homolog (PTEN) expression in prostate cancer cells. Until now, little is known about the clinical significance of miR-153 expression in prostate cancer.The miR-153 expression in 143 pairs of prostate cancer and adjacent non-cancerous prostate tissues was measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. Student t test was conducted for intergroup comparison. Pearson correlation test was used for correlation analysis. Survival curves were carried out by the Kaplan-Meier method and evaluated using the log-rank test. Multivariable Cox proportional hazard risk regression model was performed to screen the independent factor affected the prognosis of prostate cancer patients.qRT-PCR analysis showed that the expression of miR-153 was significantly increased in the prostate cancer tissues in comparison with the adjacent noncancerous prostate tissues (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000016705