In-vivo metabolic studies of regional adipose tissue

The accumulation of abdominal adipose tissue has long been associated with adverse cardiovascular outcomes. Paradoxically, increased gluteofemoral adipose tissue, which is predominantly subcutaneous fat, seems to play a protective role. There has been significant scientific interest in understanding...

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Published in:Cardiovascular endocrinology & metabolism 2018-12, Vol.7 (4), p.75-79
Main Authors: Melvin, Audrey, McQuaid, Siobhán E.
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Review
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description The accumulation of abdominal adipose tissue has long been associated with adverse cardiovascular outcomes. Paradoxically, increased gluteofemoral adipose tissue, which is predominantly subcutaneous fat, seems to play a protective role. There has been significant scientific interest in understanding how abdominal and gluteofemoral depots confer opposing metabolic risks. However, the study of regional adipose physiology in vivo remains challenging. We discuss some of the methodologies used. We focus specifically on the arteriovenous difference technique and present some insights into gluteofemoral adipose physiology.
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title In-vivo metabolic studies of regional adipose tissue
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