Expression of activation‐induced cytidine deaminase decreases throughout the life

Activation‐induced cytidine deaminase (AID) is an RNA editing enzyme, which contributes to generation of new functional genes from a restricted number of genes of plant and animal genome. This enzyme was involved in the process of somatic mutation and class switching in vertebrate. Since the rate of...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2003-04, Vol.7 (2), p.141-145
Main Authors: Radu, D. L., Kodera, T., Bona, C.
Format: Article
Language:English
Subjects:
Activation-induced cytidine deaminase
aging
Aging - physiology
AID
Animals
B-Lymphocytes - cytology
B-Lymphocytes - drug effects
B-Lymphocytes - physiology
Cells, Cultured
Class switching
Cytidine deaminase
Cytidine Deaminase - genetics
Cytidine Deaminase - metabolism
Humans
Lipopolysaccharides - pharmacology
Lymphocyte Activation
Lymphocytes B
Mice
Mice, Inbred BALB C
Mutation
Ontogeny
Phenotype
Phenotypic variations
RNA editing
somatic mutation
Spleen - cytology
Transcription, Genetic
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Summary:Activation‐induced cytidine deaminase (AID) is an RNA editing enzyme, which contributes to generation of new functional genes from a restricted number of genes of plant and animal genome. This enzyme was involved in the process of somatic mutation and class switching in vertebrate. Since the rate of somatic mutations is variable throughout ontogeny, we have studied the transcription of AID in 3 to 24 month‐old Balb/c mice. Our results demonstrate a significant decrease of the transcription of the AID gene with aging. The decreased AID activity is not related to variation of phenotypic and functional properties of B cells throughout the life. This observation can explain the low rate of somatic mutation in aged animals.
ISSN:1582-1838
1582-4934
DOI:10.1111/j.1582-4934.2003.tb00212.x