CD117/c‐kit positive interstitial (Cajal‐like) cells in human pancreas

We provide evidence that interstitial Cajal‐like cells, previously described in human pancreas ‐ pICC (J Cel Mol Med, 9: 169, 2005), are positive for c‐kit irrespective of immunohistochemical procedures used. Various sample types (fresh cryosections or formalin‐fixed, paraffin‐embedded specimens), v...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2005-07, Vol.9 (3), p.738-739
Main Authors: Popescu, L.M., Hinescu, M.E., Radu, E., Ciontea, Sanda M., Cretoiu, D., Leabu, M., Ardeleanu, Carmen
Format: Article
Language:English
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c-Kit protein
CD177/c‐kit
Epitopes
exocrine pancreas
immunohistochemistry
interstitial cells of Cajal
microwave antigen retrieval
Monoclonal antibodies
Pancreas
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Summary:We provide evidence that interstitial Cajal‐like cells, previously described in human pancreas ‐ pICC (J Cel Mol Med, 9: 169, 2005), are positive for c‐kit irrespective of immunohistochemical procedures used. Various sample types (fresh cryosections or formalin‐fixed, paraffin‐embedded specimens), various slide pretreatments (with or without heat‐induced epitope retrieval) or different antibodies used (Dako polyclonal or Santa Cruz monoclonal), all showed CD117‐positive pICC.
ISSN:1582-1838
1582-4934
DOI:10.1111/j.1582-4934.2005.tb00505.x