Particulate Systems for Targeting of Macrophages: Basic and Therapeutic Concepts

Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intra...

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Bibliographic Details
Published in:Journal of innate immunity 2012-01, Vol.4 (5-6), p.509-528
Main Authors: Moghimi, S.M., Parhamifar, L., Ahmadvand, D., Wibroe, P.P., Andresen, T.L., Farhangrazi, Z.S., Hunter, A.C.
Format: Article
Language:English
Subjects:
Animals
Drug Carriers - administration & dosage
Drug Carriers - chemistry
Drug delivery
Drug Delivery Systems - methods
Drugs
Humans
Hydrodynamics
Liposomes
Macrophages
Macrophages - drug effects
Mice
Micelles
microparticles
Nanoparticles - administration & dosage
Nanotechnology
Phagocytosis - drug effects
Phagocytosis - physiology
Physicochemical properties
Rabbits
Rats
Review
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Summary:Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug release processes can be optimized through modifications of the drug carrier physicochemical properties, which include hydrodynamic size, shape, composition and surface characteristics. Through such modifications together with understanding of macrophage cell biology, targeting may be aimed at a particular subset of macrophages. Advances in basic and therapeutic concepts of particulate targeting of macrophages and related nanotechnology approaches for immune cell modifications are discussed.
ISSN:1662-811X
1662-8128
DOI:10.1159/000339153