A Mixed-Methods Study Examining Adherence to and Acceptability of Intravaginal Rings for HIV Prevention: Behavioral Results of MTN-027

Intravaginal rings (IVR) containing antiretroviral drugs are a promising method for HIV prevention. We triangulated quantitative and qualitative assessments to evaluate the acceptability of four IVRs used continuously for 28 days as part of a Phase I trial (N = 48 HIV-negative women; ages 18–45). Ad...

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Bibliographic Details
Published in:AIDS and behavior 2020-02, Vol.24 (2), p.607-616
Main Authors: Bauermeister, José A., Golinkoff, Jesse M., Carballo-Diéguez, Alex, Giguere, Rebecca, López, Daniela, Hoesley, Craig J., Chen, Beatrice A., Anderson, Peter, Dezzutti, Charlene S., Strizki, Julie, Sprinkle, Carol, Heard, Faye, Hall, Wayne, Jacobson, Cindy, Berthiaume, Jennifer, Mayo, Ashley, Richardson, Barbra A., Piper, Jeanna
Format: Article
Language:English
Subjects:
Acceptability
Adhesion
Administration, Intravaginal
Adolescent
Adult
Anti-Infective Agents - administration & dosage
Anti-Retroviral Agents - administration & dosage
Antiretroviral agents
Antiretroviral drugs
Disease prevention
Female
Health Psychology
HIV
HIV Infections - prevention & control
Human immunodeficiency virus
Humans
Infectious Diseases
Interviews as Topic
Medication Adherence
Medicine
Medicine & Public Health
Middle Aged
Mixed methods research
Original Paper
Patient Acceptance of Health Care
Prescription drugs
Prevention
Public Health
Qualitative Research
Sexual Behavior
United States
Vagina
Vaginal Creams, Foams, and Jellies - therapeutic use
Womens health
Young Adult
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Summary:Intravaginal rings (IVR) containing antiretroviral drugs are a promising method for HIV prevention. We triangulated quantitative and qualitative assessments to evaluate the acceptability of four IVRs used continuously for 28 days as part of a Phase I trial (N = 48 HIV-negative women; ages 18–45). Adherence was high throughout the trial, yet 30% of participants reported involuntary IVR expulsions followed by re-insertion. Most participants (93.6%) felt comfortable with the IVR being inside their body. Participants reported liking the IVR more (36.2%) or the same amount (55.3%) since starting the study. When given the option of choosing between the IVR and/or a male condom for HIV-prevention, most reported preferring the IVR (n = 29, 63.0%), and over a quarter of the sample reported liking them equally (n = 12, 26.1%). We observed no differences in IVR acceptability across the study arms. High adherence and acceptability underscores the promise of an IVR as a female-controlled, sustained mechanism for HIV prevention.
ISSN:1090-7165
1573-3254
DOI:10.1007/s10461-019-02457-0