The Hippo Signaling Pathway in Development and Disease

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseas...

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Bibliographic Details
Published in:Developmental cell 2019-08, Vol.50 (3), p.264-282
Main Authors: Zheng, Yonggang, Pan, Duojia
Format: Article
Language:English
Subjects:
actomyosin
adherens junction
Animals
cancer
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
cell polarity
cytoskeleton
Exosome Multienzyme Ribonuclease Complex - genetics
Exosome Multienzyme Ribonuclease Complex - metabolism
Gene Expression Regulation, Developmental
growth control
hippo signaling
Humans
mechanotransduction
merlin
Neoplasms - genetics
Neoplasms - metabolism
neurofibromatosis
NF2
oncogene
regeneration
scalloped
Signal Transduction
spectrin
TAZ
TEAD
tissue homeostasis
Transcription Factors - genetics
Transcription Factors - metabolism
tumor suppressor
YAP
yorkie
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Summary:The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies. The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in multiple human diseases. This Review from Zheng and Pan provides an updated overview of the pathway and its roles in development, homeostasis, and disease. The authors also discuss outstanding questions and opportunities for Hippo-targeted therapies.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2019.06.003