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The Hippo Signaling Pathway in Development and Disease
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseas...
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| Published in: | Developmental cell 2019-08, Vol.50 (3), p.264-282 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c529t-d64abc2c2691dfe169bcb2841b2d53286b11dafb717b981bee58556843d6df0b3 |
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| cites | cdi_FETCH-LOGICAL-c529t-d64abc2c2691dfe169bcb2841b2d53286b11dafb717b981bee58556843d6df0b3 |
| container_end_page | 282 |
| container_issue | 3 |
| container_start_page | 264 |
| container_title | Developmental cell |
| container_volume | 50 |
| creator | Zheng, Yonggang Pan, Duojia |
| description | The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in multiple human diseases. This Review from Zheng and Pan provides an updated overview of the pathway and its roles in development, homeostasis, and disease. The authors also discuss outstanding questions and opportunities for Hippo-targeted therapies. |
| doi_str_mv | 10.1016/j.devcel.2019.06.003 |
| format | article |
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The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in multiple human diseases. This Review from Zheng and Pan provides an updated overview of the pathway and its roles in development, homeostasis, and disease. The authors also discuss outstanding questions and opportunities for Hippo-targeted therapies.</description><subject>actomyosin</subject><subject>adherens junction</subject><subject>Animals</subject><subject>cancer</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>cell polarity</subject><subject>cytoskeleton</subject><subject>Exosome Multienzyme Ribonuclease Complex - genetics</subject><subject>Exosome Multienzyme Ribonuclease Complex - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>growth control</subject><subject>hippo signaling</subject><subject>Humans</subject><subject>mechanotransduction</subject><subject>merlin</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>neurofibromatosis</subject><subject>NF2</subject><subject>oncogene</subject><subject>regeneration</subject><subject>scalloped</subject><subject>Signal Transduction</subject><subject>spectrin</subject><subject>TAZ</subject><subject>TEAD</subject><subject>tissue homeostasis</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>tumor suppressor</subject><subject>YAP</subject><subject>yorkie</subject><issn>1534-5807</issn><issn>1878-1551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kFtLxDAQhYMo3v-BSB99ac2kTZq-COJ6A0FBfQ65THezdNvadFf890bW64tPMzBzzpz5CDkCmgEFcTrPHK4sNhmjUGVUZJTmG2QXZClT4Bw2Y8_zIuWSljtkL4Q5jTKQdJvs5JBLIQXsEvE0w-TG932XPPppqxvfTpMHPc5e9Vvi22SCK2y6foHtmOjWJRMfUAc8IFu1bgIeftZ98nx1-XRxk97dX99enN-llrNqTJ0otLHMMlGBqxFEZaxhsgDDHM-ZFAbA6dqUUJpKgkHkknMhi9wJV1OT75OztW-_NAt0NsYYdKP6wS_08KY67dXfSetnatqtlCgLSQsZDU4-DYbuZYlhVAsfIrVGt9gtg2IxWkEZ5yyuFutVO3QhDFh_nwGqPpCruVojVx_IFRUqIo-y498Rv0VfjH9-wAhq5XFQwXpsLTo_oB2V6_z_F94BIcqUfg</recordid><startdate>20190805</startdate><enddate>20190805</enddate><creator>Zheng, Yonggang</creator><creator>Pan, Duojia</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190805</creationdate><title>The Hippo Signaling Pathway in Development and Disease</title><author>Zheng, Yonggang ; Pan, Duojia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-d64abc2c2691dfe169bcb2841b2d53286b11dafb717b981bee58556843d6df0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>actomyosin</topic><topic>adherens junction</topic><topic>Animals</topic><topic>cancer</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>cell polarity</topic><topic>cytoskeleton</topic><topic>Exosome Multienzyme Ribonuclease Complex - genetics</topic><topic>Exosome Multienzyme Ribonuclease Complex - metabolism</topic><topic>Gene Expression Regulation, Developmental</topic><topic>growth control</topic><topic>hippo signaling</topic><topic>Humans</topic><topic>mechanotransduction</topic><topic>merlin</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>neurofibromatosis</topic><topic>NF2</topic><topic>oncogene</topic><topic>regeneration</topic><topic>scalloped</topic><topic>Signal Transduction</topic><topic>spectrin</topic><topic>TAZ</topic><topic>TEAD</topic><topic>tissue homeostasis</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>tumor suppressor</topic><topic>YAP</topic><topic>yorkie</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Yonggang</creatorcontrib><creatorcontrib>Pan, Duojia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Developmental cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Yonggang</au><au>Pan, Duojia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Hippo Signaling Pathway in Development and Disease</atitle><jtitle>Developmental cell</jtitle><addtitle>Dev Cell</addtitle><date>2019-08-05</date><risdate>2019</risdate><volume>50</volume><issue>3</issue><spage>264</spage><epage>282</epage><pages>264-282</pages><issn>1534-5807</issn><eissn>1878-1551</eissn><abstract>The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in multiple human diseases. This Review from Zheng and Pan provides an updated overview of the pathway and its roles in development, homeostasis, and disease. The authors also discuss outstanding questions and opportunities for Hippo-targeted therapies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31386861</pmid><doi>10.1016/j.devcel.2019.06.003</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1534-5807 |
| ispartof | Developmental cell, 2019-08, Vol.50 (3), p.264-282 |
| issn | 1534-5807 1878-1551 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6748048 |
| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | actomyosin adherens junction Animals cancer Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism cell polarity cytoskeleton Exosome Multienzyme Ribonuclease Complex - genetics Exosome Multienzyme Ribonuclease Complex - metabolism Gene Expression Regulation, Developmental growth control hippo signaling Humans mechanotransduction merlin Neoplasms - genetics Neoplasms - metabolism neurofibromatosis NF2 oncogene regeneration scalloped Signal Transduction spectrin TAZ TEAD tissue homeostasis Transcription Factors - genetics Transcription Factors - metabolism tumor suppressor YAP yorkie |
| title | The Hippo Signaling Pathway in Development and Disease |
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