Methicillin-resistant Staphylococcus aureus (MRSA): antibiotic-resistance and the biofilm phenotype

( ) is an asymptomatic colonizer of 30% of all human beings. While generally benign, antibiotic resistance contributes to the success of as a human pathogen. Resistance is rapidly evolved through a wide portfolio of mechanisms including horizontal gene transfer and chromosomal mutation. In addition...

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Bibliographic Details
Published in:MedChemComm 2019-08, Vol.10 (8), p.1231-1241
Main Authors: Craft, Kelly M, Nguyen, Johny M, Berg, Lawrence J, Townsend, Steven D
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antibiotics
Biofilms
Chemistry
Drug resistance
Gene transfer
Health risks
Infections
Methicillin
Multidrug resistance
Mutation
Nosocomial infections
Pathogenesis
Pathogens
Phenotypes
Staphylococcus aureus
Staphylococcus infections
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Summary:( ) is an asymptomatic colonizer of 30% of all human beings. While generally benign, antibiotic resistance contributes to the success of as a human pathogen. Resistance is rapidly evolved through a wide portfolio of mechanisms including horizontal gene transfer and chromosomal mutation. In addition to traditional resistance mechanisms, a special feature of pathogenesis is its ability to survive on both biotic and abiotic surfaces in the biofilm state. Due to this characteristic, is a leading cause of human infection. Methicillin-resistant (MRSA) in particular has emerged as a widespread cause of both community- and hospital-acquired infections. Currently, MRSA is responsible for 10-fold more infections than all multi-drug resistant (MDR) Gram-negative pathogens combined. Recently, MRSA was classified by the World Health Organization (WHO) as one of twelve priority pathogens that threaten human health. In this targeted mini-review, we discuss MRSA biofilm production, the relationship of biofilm production to antibiotic resistance, and front-line techniques to defeat the biofilm-resistance system.
ISSN:2040-2503
2040-2511
2040-2511
DOI:10.1039/c9md00044e