Obesity and nonalcoholic fatty liver disease associated with adenocarcinoma in patients with lung cancer

Lung cancer has become the leading cause of cancer-related deaths around the world. In addition to genetic risk factors and smoking, the metabolic risk factors remain to be elusive.To evaluate the associations between obesity, nonalcoholic fatty liver disease (NAFLD) and pulmonary adenocarcinoma in...

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Published in:Medicine (Baltimore) 2019-09, Vol.98 (37), p.e17098-e17098
Main Authors: Zhu, Chan-Yan, Qu, Ji-Chen, Cao, Hai-Xia, Chen, Guang-Yu, Shi, Yi-Hai, Fan, Jian-Gao
Format: Article
Language:English
Subjects:
Adenocarcinoma - epidemiology
Adenocarcinoma - etiology
Adolescent
Adult
Aged
Aged, 80 and over
China - epidemiology
Female
Humans
Logistic Models
Lung Neoplasms - classification
Lung Neoplasms - epidemiology
Lung Neoplasms - surgery
Male
Middle Aged
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - epidemiology
Obesity - complications
Obesity - epidemiology
Observational Study
Retrospective Studies
Risk Factors
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Summary:Lung cancer has become the leading cause of cancer-related deaths around the world. In addition to genetic risk factors and smoking, the metabolic risk factors remain to be elusive.To evaluate the associations between obesity, nonalcoholic fatty liver disease (NAFLD) and pulmonary adenocarcinoma in patients with lung cancer.Consecutive operation-proven lung cancer patients with assessment of metabolic disorders and liver ultrasound in 2009 and 2013 were retrospectively enrolled. T-test and multivariate logistic regression were applied to evaluate the contribution of individual factors to lung adenocarcinoma, as well as the synergistic effects between these factors.Among 3664 lung cancer patients with ultrasound examination, 2844 cases were enrolled for further analysis. Of them, 1053 (37.0%) were females, 1242 (43.7%) were cigarette smokers, 1658 (58.3%) were diagnosed as lung adenocarcinoma, 744 (26.2%) had obesity, and 614 (21.6%) had NAFLD. Proportion of female gender, nonsmoker, obesity, NAFLD, and serum lipid levels in patients with adenocarcinoma were significantly higher than those in other subtypes of lung cancer, and in 2013 than in 2009 (all P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000017098