Synchronous retroperitoneal Castleman’s disease with clear cell renal cell carcinoma

Castleman’s disease is a rare non-clonal lymphoproliferative disorder and known to be associated with a number of disorders such as polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome, Kaposi sarcoma, paraneoplastic pemphigus and plasma cell dyscrasias. The ass...

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Bibliographic Details
Published in:BMJ case reports 2019-09, Vol.12 (9), p.e230919
Main Authors: Vishwajeet, Vikarn, Kakkar, Nandita, Singhal, Paras, Mandal, Arup Kumar
Format: Article
Language:English
Subjects:
Abdomen
Carcinoma, Renal Cell - diagnostic imaging
Carcinoma, Renal Cell - surgery
Case reports
Castleman Disease - diagnostic imaging
Castleman Disease - surgery
Cytokines
Diagnosis, Differential
Female
Humans
Kaposis sarcoma
Kidney cancer
Kidney Neoplasms - diagnostic imaging
Kidney Neoplasms - surgery
Lymphatic system
Medical imaging
Middle Aged
Neoplasms, Multiple Primary
Nephrectomy
Retroperitoneal Neoplasms - diagnostic imaging
Retroperitoneal Neoplasms - surgery
Tomography, X-Ray Computed
Unusual Association of Diseases/Symptoms
Urological cancer
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Summary:Castleman’s disease is a rare non-clonal lymphoproliferative disorder and known to be associated with a number of disorders such as polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome, Kaposi sarcoma, paraneoplastic pemphigus and plasma cell dyscrasias. The association of Castleman’s disease with epithelial malignancy is not clear and limited to few case reports. We describe a case of synchronous Castleman’s disease with renal cell carcinoma in a 53-year-old woman. She presented with right abdominal lump with feeling of heaviness. She also presented with vague discomfort in left hypochondrium for 15 years. The CT imaging of abdomen revealed two masses—one in right kidney and another in left anterior pararenal space of retroperitoneum. The patient underwent right radical nephrectomy with excision of left retroperitoneal mass. Histological examination revealed clear cell renal cell carcinoma and Castleman’s disease, respectively. Role of interleukin-6 has been postulated as an important factor in association of Castleman’s disease and epithelial malignancy.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2019-230919