Opportunities in Novel Psychotropic Drug Design from Natural Compounds

Multiple initiatives at the national and international level support natural drug discovery. Psychiatrists and patients are not well informed about natural psychotropics in general. Existing antidepressant and antipsychotic drugs were developed from atropine, a natural product. Subsequent drug devel...

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Bibliographic Details
Published in:The international journal of neuropsychopharmacology 2019-09, Vol.22 (9), p.601-607
Main Authors: Tang, Siu Wa, Tang, Wayne H
Format: Article
Language:English
Subjects:
Anopheles
Antidepressants
Antipsychotic agents
Artemisinin
Artists
Biological Products - therapeutic use
Central nervous system agents
Chemical properties
Drug Design
Drug Development - methods
Drug discovery
Drugs
Hallucinogenic drugs
Health aspects
Humans
Methods
Pharmacological research
Phytochemicals
Phytochemicals - therapeutic use
Psychiatrists
Psychotropic drugs
Psychotropic Drugs - therapeutic use
Public health
Review
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Description
Summary:Multiple initiatives at the national and international level support natural drug discovery. Psychiatrists and patients are not well informed about natural psychotropics in general. Existing antidepressant and antipsychotic drugs were developed from atropine, a natural product. Subsequent drug developments were largely based on extension and modification of earlier molecular scaffolds. This limits their mechanisms of action to similar neuropathways. Natural psychotropic substances, particularly those with hallucinogenic and psychedelic properties and different chemical structures, may serve as new paths to novel psychotropic drug development.
ISSN:1461-1457
1469-5111
DOI:10.1093/ijnp/pyz042