Effect of physical fitness on colorectal tumor development in patients with familial adenomatous polyposis

Although accumulated epidemiological evidence indicates that a good physical fitness level may prevent the development of sporadic colorectal cancer (CRC), few studies have examined the effect of physical fitness level on familial adenomatous polyposis (FAP). This cross-sectional study aimed to exam...

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-09, Vol.98 (38), p.e17076-e17076
Main Authors: Nakamura, Tomiyo, Ishikawa, Hideki, Sakai, Toshiyuki, Ayabe, Makoto, Wakabayashi, Keiji, Mutoh, Michihiro, Matsuura, Nariaki
Format: Article
Language:English
Subjects:
Adenoma - etiology
Adenoma - prevention & control
Adenomatous Polyposis Coli - complications
Adolescent
Adult
Aged
Colorectal Neoplasms - etiology
Colorectal Neoplasms - prevention & control
Cross-Sectional Studies
Exercise Test
Female
Humans
Male
Middle Aged
Observational Study
Physical Fitness
Risk Factors
Young Adult
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Summary:Although accumulated epidemiological evidence indicates that a good physical fitness level may prevent the development of sporadic colorectal cancer (CRC), few studies have examined the effect of physical fitness level on familial adenomatous polyposis (FAP). This cross-sectional study aimed to examine the relationship between physical fitness and CRC development in patients with FAP.A total of 119 patients (54 male; 65 female) with FAP, aged 17 to 73 years, underwent a step test to induce exercise stress. Predicted maximal oxygen uptake (VO2max) was calculated for each patient by using heart rate as an index of physical fitness. The association of VO2max with the presence or absence of CRC and polyp diameter was examined. Patients with FAP were divided into 3 categories according to their VO2max (high, medium, and low). The association between maximum polyp size and VO2max among the patients with FAP without a history of colectomy was examined.The risk of CRC was significantly higher in the low VO2max group than in the high VO2max group (odds ratio = 4.07; 95% confidence interval, 1.02-16.26). The maximum polyp diameter was significantly negatively correlated with the VO2max among the patients with FAP without a history of colectomy (r = -.44, P = .01). In the multiple linear regression analysis, maximum polyp diameter was independently correlated with VO2max.Our results suggest a preventive association between physical fitness and CRC development or colorectal adenoma growth exists in patients with FAP.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000017076