Spatio-angular filter (SAF) imaging device for deep interrogation of scattering media

Optical microscopy is limited to shallow interrogation depths as high-resolution imaging in scattering media is challenging. Current methods require complex and expensive experimental setup or suffer from low resolution. Through gating of photons exiting the scattering media using a restricted numer...

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Bibliographic Details
Published in:Biomedical optics express 2019-09, Vol.10 (9), p.4656-4663
Main Authors: Pandya, Aditya, Schelkanova, Irina, Douplik, Alexandre
Format: Article
Language:English
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Summary:Optical microscopy is limited to shallow interrogation depths as high-resolution imaging in scattering media is challenging. Current methods require complex and expensive experimental setup or suffer from low resolution. Through gating of photons exiting the scattering media using a restricted numerical aperture (NA) fiber optic plate (FOP), we establish a novel spatio-angular filter imaging device that allows deeper imaging in scattering media. Using dilutions of Intralipid (1-4 v/v%) and a USAF resolution target, it is shown that by reducing the NA of the FOP from 0.55 to 0.17, the interrogation depth improves ~2 times using trans-illumination.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.10.004656