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Levels of nitric oxide metabolites, adiponectin and endothelin are associated with SNPs of the adiponectin and endothelin genes
Adiponectin, endothelin and nitric oxide (NO) are major regulators of vascular function. An imbalance of vasoactive factors contributes to the onset and progression of atherosclerosis. Various single nucleotide polymorphisms (SNPs) are considered to be risk factors for coronary heart disease. Howeve...
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Published in: | Biomedical reports 2019-10, Vol.11 (4), p.154-164 |
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creator | Gumanova, Nadezhda G Klimushina, Marina V Smetnev, Stepan A Kiseleva, Anna V Skirko, Olga P Meshkov, Alexey N Shanoyan, Artem S Kots, Alexander Y Metelskaya, Victoria A |
description | Adiponectin, endothelin and nitric oxide (NO) are major regulators of vascular function. An imbalance of vasoactive factors contributes to the onset and progression of atherosclerosis. Various single nucleotide polymorphisms (SNPs) are considered to be risk factors for coronary heart disease. However, the molecular mechanisms of their associations with the components of endothelial dysfunction are poorly understood. In the present study, rs17366743, rs17300539, rs266729, rs182052 and rs2241766 SNPs of the adiponectin (ADIPOQ) gene and rs2070699, rs1800542 and rs1800543 SNPs of the endothelin-1 (EDN1) gene were genotyped in 477 patients with coronary heart disease who were subjected to coronary angiography, in order to determine the presence or absence of coronary atherosclerosis. The serum levels of adiponectin, endothelin and stable metabolites of NO, (nitrate and nitrite NOx), were assayed and their associations with the SNP genotypes and coronary lesions were calculated. The results indicated that rs17366743 of the ADIPOQ gene and rs2070699 and rs1800543 of the EDN1 gene were associated with the levels of NOx in women, which in turn was associated with cardiovascular mortality. In men, rs182052 and rs266729 of the ADIPOQ gene were associated with adiponectin levels, whereas rs17366743 of the ADIPOQ gene was associated with endothelin levels. Additionally, these SNPs were indirectly associated with the prevalence of coronary lesions in men. Therefore, the tested SNPs can be considered potential risk factors that lead to imbalance of vasoactive mediators in a gender-specific manner and contribute to the development of clinical manifestations of atherosclerosis. |
doi_str_mv | 10.3892/br.2019.1238 |
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An imbalance of vasoactive factors contributes to the onset and progression of atherosclerosis. Various single nucleotide polymorphisms (SNPs) are considered to be risk factors for coronary heart disease. However, the molecular mechanisms of their associations with the components of endothelial dysfunction are poorly understood. In the present study, rs17366743, rs17300539, rs266729, rs182052 and rs2241766 SNPs of the adiponectin (ADIPOQ) gene and rs2070699, rs1800542 and rs1800543 SNPs of the endothelin-1 (EDN1) gene were genotyped in 477 patients with coronary heart disease who were subjected to coronary angiography, in order to determine the presence or absence of coronary atherosclerosis. The serum levels of adiponectin, endothelin and stable metabolites of NO, (nitrate and nitrite NOx), were assayed and their associations with the SNP genotypes and coronary lesions were calculated. The results indicated that rs17366743 of the ADIPOQ gene and rs2070699 and rs1800543 of the EDN1 gene were associated with the levels of NOx in women, which in turn was associated with cardiovascular mortality. In men, rs182052 and rs266729 of the ADIPOQ gene were associated with adiponectin levels, whereas rs17366743 of the ADIPOQ gene was associated with endothelin levels. Additionally, these SNPs were indirectly associated with the prevalence of coronary lesions in men. Therefore, the tested SNPs can be considered potential risk factors that lead to imbalance of vasoactive mediators in a gender-specific manner and contribute to the development of clinical manifestations of atherosclerosis.</description><identifier>ISSN: 2049-9434</identifier><identifier>EISSN: 2049-9442</identifier><identifier>DOI: 10.3892/br.2019.1238</identifier><identifier>PMID: 31565221</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Adiponectin ; Angina pectoris ; Angiography ; Arteriosclerosis ; Atherosclerosis ; Biomarkers ; Cardiovascular disease ; Cardiovascular diseases ; Chromosomes ; Coronary artery disease ; Coronary heart disease ; Deoxyribonucleic acid ; Diabetes ; Diagnostic imaging ; DNA ; EDN1 gene ; Endothelin ; Endothelin 1 ; Endothelins ; Endothelium ; Genes ; Genetic polymorphisms ; Genotype & phenotype ; Genotypes ; Heart diseases ; Lesions ; Medical imaging ; Medical research ; Metabolites ; Molecular modelling ; Nitric oxide ; Nitrogen oxides ; Nucleotides ; Polymorphism ; Preventive medicine ; Regulators ; Risk analysis ; Risk factors ; Serum levels ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Studies ; Thermal cycling ; Vasoactive agents</subject><ispartof>Biomedical reports, 2019-10, Vol.11 (4), p.154-164</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Gumanova et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-41c62d394fe8e7f30ea284448a6bbd8f82425911cd7d240bbd70154b08ce643d3</citedby><cites>FETCH-LOGICAL-c456t-41c62d394fe8e7f30ea284448a6bbd8f82425911cd7d240bbd70154b08ce643d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759535/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759535/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Gumanova, Nadezhda G</creatorcontrib><creatorcontrib>Klimushina, Marina V</creatorcontrib><creatorcontrib>Smetnev, Stepan A</creatorcontrib><creatorcontrib>Kiseleva, Anna V</creatorcontrib><creatorcontrib>Skirko, Olga P</creatorcontrib><creatorcontrib>Meshkov, Alexey N</creatorcontrib><creatorcontrib>Shanoyan, Artem S</creatorcontrib><creatorcontrib>Kots, Alexander Y</creatorcontrib><creatorcontrib>Metelskaya, Victoria A</creatorcontrib><title>Levels of nitric oxide metabolites, adiponectin and endothelin are associated with SNPs of the adiponectin and endothelin genes</title><title>Biomedical reports</title><description>Adiponectin, endothelin and nitric oxide (NO) are major regulators of vascular function. An imbalance of vasoactive factors contributes to the onset and progression of atherosclerosis. Various single nucleotide polymorphisms (SNPs) are considered to be risk factors for coronary heart disease. However, the molecular mechanisms of their associations with the components of endothelial dysfunction are poorly understood. In the present study, rs17366743, rs17300539, rs266729, rs182052 and rs2241766 SNPs of the adiponectin (ADIPOQ) gene and rs2070699, rs1800542 and rs1800543 SNPs of the endothelin-1 (EDN1) gene were genotyped in 477 patients with coronary heart disease who were subjected to coronary angiography, in order to determine the presence or absence of coronary atherosclerosis. The serum levels of adiponectin, endothelin and stable metabolites of NO, (nitrate and nitrite NOx), were assayed and their associations with the SNP genotypes and coronary lesions were calculated. The results indicated that rs17366743 of the ADIPOQ gene and rs2070699 and rs1800543 of the EDN1 gene were associated with the levels of NOx in women, which in turn was associated with cardiovascular mortality. In men, rs182052 and rs266729 of the ADIPOQ gene were associated with adiponectin levels, whereas rs17366743 of the ADIPOQ gene was associated with endothelin levels. Additionally, these SNPs were indirectly associated with the prevalence of coronary lesions in men. Therefore, the tested SNPs can be considered potential risk factors that lead to imbalance of vasoactive mediators in a gender-specific manner and contribute to the development of clinical manifestations of atherosclerosis.</description><subject>Adiponectin</subject><subject>Angina pectoris</subject><subject>Angiography</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Chromosomes</subject><subject>Coronary artery disease</subject><subject>Coronary heart disease</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>Diagnostic imaging</subject><subject>DNA</subject><subject>EDN1 gene</subject><subject>Endothelin</subject><subject>Endothelin 1</subject><subject>Endothelins</subject><subject>Endothelium</subject><subject>Genes</subject><subject>Genetic polymorphisms</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Heart diseases</subject><subject>Lesions</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Metabolites</subject><subject>Molecular modelling</subject><subject>Nitric oxide</subject><subject>Nitrogen oxides</subject><subject>Nucleotides</subject><subject>Polymorphism</subject><subject>Preventive medicine</subject><subject>Regulators</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Serum levels</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>Thermal cycling</subject><subject>Vasoactive agents</subject><issn>2049-9434</issn><issn>2049-9442</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kk1rFTEUhgdRbKnd-QMCblz0XvM9yUYopX7ARQV1HTLJmXtTZpJrklt15V8305ZKRUwWOTl53jecw-m65wSvmdL01ZDXFBO9JpSpR90xxVyvNOf08X3M-FF3WsoVbkv3mAr1tDtiREhBKTnufm3gGqaC0ohiqDk4lH4ED2iGaoc0hQrlDFkf9imCqyEiGz2C6FPdwbRcMyBbSnLBVvDoe6g79PnDpxvDhvxPuoUI5Vn3ZLRTgdO786T7-ubyy8W71ebj2_cX55uV40LWFSdOUs80H0FBPzIMlirOubJyGLwaFeVUaEKc7z3luOV6TAQfsHIgOfPspHt967s_DDN4B7FmO5l9DrPNP02ywTx8iWFntunayF5owUQzeHlnkNO3A5Rq5lAcTJONkA7FUKpb43vCSENf_IVepUOOrbwbCveKcPmH2toJTIhjav-6xdScS0w17aXgjVr_g2rbwxxc6-wYWv6B4OxW4HIqJcN4XyPBZpkZM2SzzIxZZob9BuIsss8</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Gumanova, Nadezhda G</creator><creator>Klimushina, Marina V</creator><creator>Smetnev, Stepan A</creator><creator>Kiseleva, Anna V</creator><creator>Skirko, Olga P</creator><creator>Meshkov, Alexey N</creator><creator>Shanoyan, Artem S</creator><creator>Kots, Alexander Y</creator><creator>Metelskaya, Victoria A</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191001</creationdate><title>Levels of nitric oxide metabolites, adiponectin and endothelin are associated with SNPs of the adiponectin and endothelin genes</title><author>Gumanova, Nadezhda G ; Klimushina, Marina V ; Smetnev, Stepan A ; Kiseleva, Anna V ; Skirko, Olga P ; Meshkov, Alexey N ; Shanoyan, Artem S ; Kots, Alexander Y ; Metelskaya, Victoria A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-41c62d394fe8e7f30ea284448a6bbd8f82425911cd7d240bbd70154b08ce643d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adiponectin</topic><topic>Angina pectoris</topic><topic>Angiography</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Chromosomes</topic><topic>Coronary artery disease</topic><topic>Coronary heart disease</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>Diagnostic imaging</topic><topic>DNA</topic><topic>EDN1 gene</topic><topic>Endothelin</topic><topic>Endothelin 1</topic><topic>Endothelins</topic><topic>Endothelium</topic><topic>Genes</topic><topic>Genetic polymorphisms</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Heart diseases</topic><topic>Lesions</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Metabolites</topic><topic>Molecular modelling</topic><topic>Nitric oxide</topic><topic>Nitrogen oxides</topic><topic>Nucleotides</topic><topic>Polymorphism</topic><topic>Preventive medicine</topic><topic>Regulators</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Serum levels</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Studies</topic><topic>Thermal cycling</topic><topic>Vasoactive agents</topic><toplevel>online_resources</toplevel><creatorcontrib>Gumanova, Nadezhda G</creatorcontrib><creatorcontrib>Klimushina, Marina V</creatorcontrib><creatorcontrib>Smetnev, Stepan A</creatorcontrib><creatorcontrib>Kiseleva, Anna V</creatorcontrib><creatorcontrib>Skirko, Olga P</creatorcontrib><creatorcontrib>Meshkov, Alexey N</creatorcontrib><creatorcontrib>Shanoyan, Artem S</creatorcontrib><creatorcontrib>Kots, Alexander Y</creatorcontrib><creatorcontrib>Metelskaya, Victoria A</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomedical reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gumanova, Nadezhda G</au><au>Klimushina, Marina V</au><au>Smetnev, Stepan A</au><au>Kiseleva, Anna V</au><au>Skirko, Olga P</au><au>Meshkov, Alexey N</au><au>Shanoyan, Artem S</au><au>Kots, Alexander Y</au><au>Metelskaya, Victoria A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levels of nitric oxide metabolites, adiponectin and endothelin are associated with SNPs of the adiponectin and endothelin genes</atitle><jtitle>Biomedical reports</jtitle><date>2019-10-01</date><risdate>2019</risdate><volume>11</volume><issue>4</issue><spage>154</spage><epage>164</epage><pages>154-164</pages><issn>2049-9434</issn><eissn>2049-9442</eissn><abstract>Adiponectin, endothelin and nitric oxide (NO) are major regulators of vascular function. An imbalance of vasoactive factors contributes to the onset and progression of atherosclerosis. Various single nucleotide polymorphisms (SNPs) are considered to be risk factors for coronary heart disease. However, the molecular mechanisms of their associations with the components of endothelial dysfunction are poorly understood. In the present study, rs17366743, rs17300539, rs266729, rs182052 and rs2241766 SNPs of the adiponectin (ADIPOQ) gene and rs2070699, rs1800542 and rs1800543 SNPs of the endothelin-1 (EDN1) gene were genotyped in 477 patients with coronary heart disease who were subjected to coronary angiography, in order to determine the presence or absence of coronary atherosclerosis. The serum levels of adiponectin, endothelin and stable metabolites of NO, (nitrate and nitrite NOx), were assayed and their associations with the SNP genotypes and coronary lesions were calculated. The results indicated that rs17366743 of the ADIPOQ gene and rs2070699 and rs1800543 of the EDN1 gene were associated with the levels of NOx in women, which in turn was associated with cardiovascular mortality. In men, rs182052 and rs266729 of the ADIPOQ gene were associated with adiponectin levels, whereas rs17366743 of the ADIPOQ gene was associated with endothelin levels. Additionally, these SNPs were indirectly associated with the prevalence of coronary lesions in men. Therefore, the tested SNPs can be considered potential risk factors that lead to imbalance of vasoactive mediators in a gender-specific manner and contribute to the development of clinical manifestations of atherosclerosis.</abstract><cop>Athens</cop><pub>Spandidos Publications</pub><pmid>31565221</pmid><doi>10.3892/br.2019.1238</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adiponectin Angina pectoris Angiography Arteriosclerosis Atherosclerosis Biomarkers Cardiovascular disease Cardiovascular diseases Chromosomes Coronary artery disease Coronary heart disease Deoxyribonucleic acid Diabetes Diagnostic imaging DNA EDN1 gene Endothelin Endothelin 1 Endothelins Endothelium Genes Genetic polymorphisms Genotype & phenotype Genotypes Heart diseases Lesions Medical imaging Medical research Metabolites Molecular modelling Nitric oxide Nitrogen oxides Nucleotides Polymorphism Preventive medicine Regulators Risk analysis Risk factors Serum levels Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Thermal cycling Vasoactive agents |
title | Levels of nitric oxide metabolites, adiponectin and endothelin are associated with SNPs of the adiponectin and endothelin genes |
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