Distribution of local ancestry and evidence of adaptation in admixed populations

Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time th...

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Bibliographic Details
Published in:Scientific reports 2019-09, Vol.9 (1), p.13900-12, Article 13900
Main Authors: Secolin, Rodrigo, Mas-Sandoval, Alex, Arauna, Lara R., Torres, Fábio R., de Araujo, Tânia K., Santos, Marilza L., Rocha, Cristiane S., Carvalho, Benilton S., Cendes, Fernando, Lopes-Cendes, Iscia, Comas, David
Format: Article
Language:English
Subjects:
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Adaptation, Physiological - genetics
Black or African American
Black People - genetics
Brazil
Chromosome 8
Chromosome rearrangements
Chromosomes - genetics
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - genetics
Evolutionary biology
Female
Genetics
Genetics, Population - methods
Genome, Human - genetics
Genomes
Haplotypes
Haplotypes - genetics
Humanities and Social Sciences
Humans
Male
multidisciplinary
Positive selection
Precision medicine
Protein Phosphatase 1 - genetics
Science
Science (multidisciplinary)
United States
White People - genetics
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Summary:Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time the distribution of local ancestry across the genome of 264 Brazilian admixed individuals, ascertained within the scope of the Brazilian Initiative on Precision Medicine. We found a decreased proportion of European ancestry together with an excess of Native-American ancestry on chromosome 8p23.1 and showed that this is due to haplotypes created by chromosomal inversion events. Furthermore, Brazilian non-inverted haplotypes were more similar to Native-American haplotypes than to European haplotypes, in contrast to what was found in other American admixed populations. We also identified signals of recent positive selection on chromosome 8p23.1, and one gene within this locus, PPP1R3B , is related to glycogenesis and has been associated with an increased risk of type 2 diabetes and obesity. These findings point to a selection event after admixture, which is still not entirely understood in recent admixture events.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-50362-2