How does Helicobacter pylori cause gastric cancer through connexins: An opinion review

( ) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A, its pathogenicity island, and lipopolysaccharide, which cause gastrointestinal diseases. Connexins function in gap junctional homeostasis, and their downregulation is cl...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2019-09, Vol.25 (35), p.5220-5232
Main Authors: Li, Huan, Xu, Can-Xia, Gong, Ren-Jie, Chi, Jing-Shu, Liu, Peng, Liu, Xiao-Ming
Format: Article
Language:English
Subjects:
Carcinogenesis - pathology
Connexins - metabolism
Down-Regulation
Gastric Mucosa - pathology
Gene Expression Regulation, Neoplastic
Genomic Islands
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter pylori - genetics
Helicobacter pylori - metabolism
Helicobacter pylori - pathogenicity
Host-Pathogen Interactions
Humans
Opinion Review
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
Virulence Factors - genetics
Virulence Factors - metabolism
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Summary:( ) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A, its pathogenicity island, and lipopolysaccharide, which cause gastrointestinal diseases. Connexins function in gap junctional homeostasis, and their downregulation is closely related to gastric carcinogenesis. Investigations into infection and the fine-tuning of connexins in cells or tissues have been reported in previous studies. Therefore, in this review, the potential mechanisms of -induced gastric cancer through connexins are summarized in detail.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v25.i35.5220