Isavuconazole Diffusion in Infected Human Brain

We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The patients required radical surgery for infection progression despite adequate isavuconazole plasma concentration or neurologica...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2019-10, Vol.63 (10)
Main Authors: Rouzaud, Claire, Jullien, Vincent, Herbrecht, Anne, Palmier, Bruno, Lapusan, Simona, Morgand, Marjolaine, Guéry, Romain, Dureault, Amélie, Danion, François, Puget, Stéphanie, Goldwirt, Lauriane, Lanternier, Fanny, Lortholary, Olivier
Format: Article
Language:English
Subjects:
Brain
Granulomatous Disease, Chronic
Nitriles
Pharmacology
Pyridines
Triazoles
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Summary:We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The patients required radical surgery for infection progression despite adequate isavuconazole plasma concentration or neurological complication. We thus decided to measure the brain isavuconazole concentration. These results suggest that the concentrations of isavuconazole obtained in the infected brain tissue clearly differ from those obtained in the normal brain tissue and the cerebrospinal fluid.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02474-18