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Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali

Rice bran supplementation provides nutrients, prebiotics and phytochemicals that enhance gut immunity, reduce enteric pathogens and diarrhea, and warrants attention for improvement of environmental enteric dysfunction (EED) in children. EED is a subclinical condition associated with stunting due to...

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Published in:Scientific reports 2019-09, Vol.9 (1), p.13919-18, Article 13919
Main Authors: Zambrana, Luis E., McKeen, Starin, Ibrahim, Hend, Zarei, Iman, Borresen, Erica C., Doumbia, Lassina, Boré, Abdoulaye, Cissoko, Alima, Douyon, Seydou, Koné, Karim, Perez, Johann, Perez, Claudia, Hess, Ann, Abdo, Zaid, Sangaré, Lansana, Maiga, Ababacar, Becker-Dreps, Sylvia, Yuan, Lijuan, Koita, Ousmane, Vilchez, Samuel, Ryan, Elizabeth P.
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cited_by cdi_FETCH-LOGICAL-c474t-a3344ffea5850e99b7dfd4efdb7fb9236140be7a5c742112d6adbd9dae908bcf3
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container_title Scientific reports
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creator Zambrana, Luis E.
McKeen, Starin
Ibrahim, Hend
Zarei, Iman
Borresen, Erica C.
Doumbia, Lassina
Boré, Abdoulaye
Cissoko, Alima
Douyon, Seydou
Koné, Karim
Perez, Johann
Perez, Claudia
Hess, Ann
Abdo, Zaid
Sangaré, Lansana
Maiga, Ababacar
Becker-Dreps, Sylvia
Yuan, Lijuan
Koita, Ousmane
Vilchez, Samuel
Ryan, Elizabeth P.
description Rice bran supplementation provides nutrients, prebiotics and phytochemicals that enhance gut immunity, reduce enteric pathogens and diarrhea, and warrants attention for improvement of environmental enteric dysfunction (EED) in children. EED is a subclinical condition associated with stunting due to impaired nutrient absorption. This study investigated the effects of rice bran supplementation on weight for age and length for age z-scores (WAZ, LAZ), EED stool biomarkers, as well as microbiota and metabolome signatures in weaning infants from 6 to 12 months old that reside in Nicaragua and Mali. Healthy infants were randomized to a control (no intervention) or a rice bran group that received daily supplementation with increasing doses at each month (1–5 g/day). Stool microbiota were characterized using 16S rDNA amplicon sequencing. Stool metabolomes were analyzed using ultra-high-performance liquid-chromatography tandem mass-spectrometry. Statistical comparisons were completed at 6, 8, and 12 months of age. Daily consumption of rice bran was safe and feasible to support changes in LAZ from 6–8 and 8–12 months of age in Nicaragua and Mali infants when compared to control. WAZ was significantly improved only for Mali infants at 8 and 12 months. Mali and Nicaraguan infants showed major differences in the overall gut microbiota and metabolome composition and structure at baseline, and thus each country cohort demonstrated distinct microbial and metabolite profile responses to rice bran supplementation when compared to control. Rice bran is a practical dietary intervention strategy that merits development in rice-growing regions that have a high prevalence of growth stunting due to malnutrition and diarrheal diseases. Rice is grown as a staple food, and the bran is used as animal feed or wasted in many low- and middle-income countries where EED and stunting is prevalent.
doi_str_mv 10.1038/s41598-019-50344-4
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WAZ was significantly improved only for Mali infants at 8 and 12 months. Mali and Nicaraguan infants showed major differences in the overall gut microbiota and metabolome composition and structure at baseline, and thus each country cohort demonstrated distinct microbial and metabolite profile responses to rice bran supplementation when compared to control. Rice bran is a practical dietary intervention strategy that merits development in rice-growing regions that have a high prevalence of growth stunting due to malnutrition and diarrheal diseases. 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WAZ was significantly improved only for Mali infants at 8 and 12 months. Mali and Nicaraguan infants showed major differences in the overall gut microbiota and metabolome composition and structure at baseline, and thus each country cohort demonstrated distinct microbial and metabolite profile responses to rice bran supplementation when compared to control. Rice bran is a practical dietary intervention strategy that merits development in rice-growing regions that have a high prevalence of growth stunting due to malnutrition and diarrheal diseases. 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subjects 631/326/2565/2134
692/308/2779/777
692/308/3187
Age
Body Size
Body Weight
Child Development
Diarrhea
Dietary fiber
Dietary Supplements - adverse effects
Feeds
Female
Gastrointestinal Microbiome
Humanities and Social Sciences
Humans
Infant
Infants
Intestinal microflora
Male
Mali
Malnutrition
Metabolites
Metabolome
Microbiota
multidisciplinary
Nicaragua
Nutrient solutions
Nutrients
Oryza - adverse effects
Prebiotics
Rice
Rice bran
rRNA 16S
Science
Science (multidisciplinary)
Spectrometry
Weaning
Whole Grains - adverse effects
title Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali
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