Effect of Specific Retinoic Acid Receptor Agonists on Noise-Induced Hearing Loss

Noise is one of the most common causes of hearing loss in industrial countries. There are many studies about chemical agents to prevent noise-induced hearing loss (NIHL). However, there is no commercially available drug yet. Retinoic acid is an active metabolite of Vitamin A; it has an anti-apoptic...

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Bibliographic Details
Published in:International journal of environmental research and public health 2019-09, Vol.16 (18), p.3428
Main Authors: Kwak, Sang Hyun, Nam, Gi-Sung, Bae, Seong Hoon, Jung, Jinsei
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Benzoates - therapeutic use
Cochlea
Degeneration
Ears & hearing
Exposure
Gene expression
Hearing
Hearing loss
Hearing Loss, Noise-Induced - prevention & control
Hearing protection
Kinases
Mice, Inbred C57BL
Naphthols - therapeutic use
Noise
Noise - adverse effects
Noise levels
Noise threshold
Receptors, Retinoic Acid - agonists
Retinoic acid
Tetrahydronaphthalenes - therapeutic use
Thiazoles - therapeutic use
Tretinoin - therapeutic use
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Summary:Noise is one of the most common causes of hearing loss in industrial countries. There are many studies about chemical agents to prevent noise-induced hearing loss (NIHL). However, there is no commercially available drug yet. Retinoic acid is an active metabolite of Vitamin A; it has an anti-apoptic role in NIHL. This study aims to verify the differences among selective agonists of retinoic acid receptors (RARs) in NIHL. All-trans retinoic acid (ATRA), AM80 (selective retinoic acid receptor α agonist), AC261066 (Selective retinoic acid receptor β1 agonist), and CD1530 (Selective retinoic acid λ agonist) were injected to 6-7 weeks old CJ5BL/6 mice before noise (110 dB for 3 h) exposure. In the auditory brainstem response test pre-, post 1, 3, and 7 days after noise exposure, not only ATRA but all kinds of selective RAR agonists showed protective effects in hearing threshold and wave I amplitude. Though there was no significant difference in the level of protective effects between agonists, α agonist showed the most prominent effect in preserving hearing function as well as outer hair cells after noise exposure. In conclusion, selective agonists of RAR demonstrate comparable protective effects against NIHL to retinoic acid. Given that these selective RAR agonists have less side effects than retinoic acid, they may be promising potential drugs against NIHL.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph16183428